Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine

被引：151
作者：
Bhatt, Prashant M. [1 ]
Azim, Yasser [1 ]
Thakur, Tejencer S. [1 ]
Desiraju, Gautam R. [1 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
CRYSTAL GROWTH & DESIGN | 2009年 / 9卷 / 02期
关键词：
SOLID-STATE; CARBOXYLIC-ACIDS; PHARMACEUTICAL COCRYSTALS; SUPRAMOLECULAR SYNTHESIS; MOLECULAR RECOGNITION; ORGANIC ALLOYS; DESIGN; WATER; COMPLEXES; SYNTHON;
D O I：
10.1021/cg8007359
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Co-crystal forming abilities of the two anti-HIV drugs lamivudine and zidovudine were studied. A study of five crystal structures was carried out to investigate the general applicability of the retrosynthetic approach in the design of new co-crystals. This analysis of co-crystals and salt structures showed a complete to partial success, and in one case, a total failure to obtain the predicted synthon. Both screening strategies and rerrosynthetic methods may be appropriate for the discovery of new active pharmaceutical ingredients co-crystals.
引用
收藏
页码：951 / 957
页数：7
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