Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine

被引：151
作者：
Bhatt, Prashant M. [1 ]
Azim, Yasser [1 ]
Thakur, Tejencer S. [1 ]
Desiraju, Gautam R. [1 ]
机构：
[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India
来源：
CRYSTAL GROWTH & DESIGN | 2009年 / 9卷 / 02期
关键词：
SOLID-STATE; CARBOXYLIC-ACIDS; PHARMACEUTICAL COCRYSTALS; SUPRAMOLECULAR SYNTHESIS; MOLECULAR RECOGNITION; ORGANIC ALLOYS; DESIGN; WATER; COMPLEXES; SYNTHON;
D O I：
10.1021/cg8007359
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Co-crystal forming abilities of the two anti-HIV drugs lamivudine and zidovudine were studied. A study of five crystal structures was carried out to investigate the general applicability of the retrosynthetic approach in the design of new co-crystals. This analysis of co-crystals and salt structures showed a complete to partial success, and in one case, a total failure to obtain the predicted synthon. Both screening strategies and rerrosynthetic methods may be appropriate for the discovery of new active pharmaceutical ingredients co-crystals.
引用
收藏
页码：951 / 957
页数：7
相关论文
共 96 条
  • [1] Balancing intermolecular hydrogen-bond interactions for the directed assembly of binary 1:1 co-crystals
    Aakeroey, Christer B.
    Schultheiss, Nate
    Desper, John
    Moore, Curtis
    [J]. NEW JOURNAL OF CHEMISTRY, 2006, 30 (10) : 1452 - 1460
  • [2] Supramolecular reagents:: versatile tools for non-covalent synthesis
    Aakeröy, CB
    Desper, J
    Urbina, JF
    [J]. CHEMICAL COMMUNICATIONS, 2005, (22) : 2820 - 2822
  • [3] Making reversible synthesis stick:: competition and cooperation between intermolecular interactions
    Aakeröy, CB
    Desper, J
    Elisabeth, E
    Helfrich, BA
    Levin, B
    Urbina, JF
    [J]. ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 2005, 220 (04): : 325 - 332
  • [4] Building co-crystals with molecular sense and supramolecular sensibility
    Aakeröy, CB
    Salmon, DJ
    [J]. CRYSTENGCOMM, 2005, 7 : 439 - 448
  • [5] Do polymorphic compounds make good cocrystallizing agents?: A structural case study that demonstrates the importance of synthon flexibility
    Aakeröy, CB
    Beatty, AM
    Helfrich, BA
    Nieuwenhuyzen, M
    [J]. CRYSTAL GROWTH & DESIGN, 2003, 3 (02) : 159 - 165
  • [6] Aakeröy CB, 2001, ANGEW CHEM INT EDIT, V40, P3240, DOI 10.1002/1521-3773(20010903)40:17<3240::AID-ANIE3240>3.0.CO
  • [7] 2-X
  • [8] Systematic analysis of the probabilities of formation of bimolecular hydrogen-bonded ring motifs in organic crystal structures
    Allen, FH
    Motherwell, WDS
    Raithby, PR
    Shields, GP
    Taylor, R
    [J]. NEW JOURNAL OF CHEMISTRY, 1999, 23 (01) : 25 - 34
  • [9] Crystal engineering of the composition of pharmaceutical phases.: Do pharmaceutical co-crystals represent a new path to improved medicines?
    Almarsson, Ö
    Zaworotko, MJ
    [J]. CHEMICAL COMMUNICATIONS, 2004, (17) : 1889 - 1896
  • [10] [Anonymous], 1998, SMART VERS 5 05
12345678910