HEART FAILURE Aldosterone antagonism for HFpEF

被引：5
作者：
Borlaug, Barry A. [1 ]
机构：
[1] Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA
来源：
NATURE REVIEWS CARDIOLOGY | 2013年 / 10卷 / 05期
关键词：
PRESERVED EJECTION FRACTION; DIASTOLIC FUNCTION; DYSFUNCTION; SPIRONOLACTONE; HYPERTENSION;
D O I：
10.1038/nrcardio.2013.51
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
No therapy has been proven to reduce morbidity and mortality in patients with heart failure and preserved ejection fraction (HFpEF). Owing to the deleterious cardiovascular effects of aldosterone, mineralocorticoid antagonists hold promise to treat this disorder. The Aldo-DHF trial provides valuable insights into the effects of these agents in HFpEF. Borlaug, B. A. Nat. Rev. Cardiol. 10, 244-246 (2013); published online 2 April 2013; doi: 10.1038/nrcardio.2013.51
引用
收藏
页码：244 / 246
页数：4
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