Interferon-ε Protects the Female Reproductive Tract from Viral and Bacterial Infection

被引：190

作者：

Fung, Ka Yee ^{[1
]}

Mangan, Niamh E. ^{[1
]}

Cumming, Helen ^{[1
]}

Horvat, Jay C. ^{[2
,3
]}

Mayall, Jemma R. ^{[2
,3
]}

Stifter, Sebastian A. ^{[1
]}

De Weerd, Nicole ^{[1
]}

Roisman, Laila C. ^{[1
,4
]}

Rossjohn, Jamie ^{[4
]}

Robertson, Sarah A. ^{[5
,6
]}

Schjenken, John E. ^{[5
,6
]}

Parker, Belinda ^{[7
,8
]}

Gargett, Caroline E. ^{[9
,10
]}

Nguyen, Hong P. T. ^{[9
]}

Carr, Daniel J. ^{[11
,12
]}

Hansbro, Philip M. ^{[2
,3
]}

Hertzog, Paul J. ^{[1
]}

机构：

[1] Monash Univ, Ctr Innate Immun & Infect Dis, Inst Med Res, Clayton, Vic, Australia

[2] Univ Newcastle, Ctr Asthma & Resp Dis, Newcastle, NSW 2300, Australia

[3] Univ Newcastle, Hunter Med Res Inst, Newcastle, NSW 2300, Australia

[4] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic, Australia

[5] Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia

[6] Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA 5005, Australia

[7] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia

[8] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3052, Australia

[9] Monash Univ, Ritchie Ctr, Monash Inst Med Res, Clayton, Vic, Australia

[10] Monash Univ, Dept Obstet & Gynaecol, Clayton, Vic 3168, Australia

[11] Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK USA

[12] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73190 USA

来源：

SCIENCE | 2013年 / 339卷 / 6123期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

CELLS; ACTIVATION; INDUCTION; IMMUNITY; RISK; DNA;

D O I：

10.1126/science.1233321

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The innate immune system senses pathogens through pattern-recognition receptors (PRRs) that signal to induce effector cytokines, such as type I interferons (IFNs). We characterized IFN-epsilon as a type I IFN because it signaled via the Ifnar1 and Ifnar2 receptors to induce IFN-regulated genes. In contrast to other type I IFNs, IFN-epsilon was not induced by known PRR pathways; instead, IFN-epsilon was constitutively expressed by epithelial cells of the female reproductive tract (FRT) and was hormonally regulated. Ifn-epsilon-deficient mice had increased susceptibility to infection of the FRT by the common sexually transmitted infections (STIs) herpes simplex virus 2 and Chlamydia muridarum. Thus, IFN-epsilon is a potent antipathogen and immunoregulatory cytokine that may be important in combating STIs that represent a major global health and socioeconomic burden.

引用

页码：1088 / 1092

页数：5

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