Extending the understanding of sensory neuropeptides

被引：84

作者：

De Swert, KO ^{[1
]}

Joos, GF ^{[1
]}

机构：

[1] Univ Ghent, Dept Resp Dis, Fac Med & Hlth Sci, B-9000 Ghent, Belgium

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2006年 / 533卷 / 1-3期

关键词：

tachykinin; substance P; neurokinin A; asthma; chronic obstructive pulmonary disease; airway inflammation;

D O I：

10.1016/j.ejphar.2005.12.066

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The tachykinins Substance P and neurokinin A are present in human airways, in sensory nerves and immune cells. Tachykinins can be recovered from the airways after inhalation of ozone, cigarette smoke or allergen. They interact in the airways with tachykinin NK1, NK2 and NK3 receptors to cause bronchoconstriction, plasma protein extravasation, and mucus secretion and to attract and activate immune cells. In preclinical studies they have been implicated in the pathophysiology of asthma and chronic obstructive pulmonary disease, including allergen- and cigarette smoke induced airway inflammation and bronchial hyperresponsiveness and mucus secretion. Dual NK1/NK2 or triple NK1/NK2/NK3 tachykinin receptor antagonists offer therapeutic potential in airway diseases Such as asthma and chronic obstructive pulmonary disease. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：171 / 181

页数：11

共 151 条

[1]

Advenier C, 1999, CLIN EXP ALLERGY, V29, P579

[2] The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough [J].

Advenier, C ;

Lagente, V ;

Boichot, E .

EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (08) :1892-1906

[3] EFFECTS ON THE ISOLATED HUMAN BRONCHUS OF SR-48968, A POTENT AND SELECTIVE NONPEPTIDE ANTAGONIST OF THE NEUROKININ-A (NK2) RECEPTORS [J].

ADVENIER, C ;

NALINE, E ;

TOTY, L ;

BAKDACH, H ;

EMONDSALT, X ;

VILAIN, P ;

BRELIERE, JC ;

LEFUR, G .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (05) :1177-1181

[4] RELATIVE POTENCIES OF NEUROKININS IN GUINEA-PIG TRACHEA AND HUMAN BRONCHUS [J].

ADVENIER, C ;

NALINE, E ;

DRAPEAU, G ;

REGOLI, D .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 139 (02) :133-137

[5] SELECTIVE LOCALIZATION OF VASOACTIVE-INTESTINAL-PEPTIDE AND SUBSTANCE-P IN HUMAN EOSINOPHILS [J].

ALIAKBARI, J ;

SREEDHARAN, SP ;

TURCK, CW ;

GOETZL, EJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (03) :1440-1445

[6] Tachykinins and tachykinin receptors:: Structure and activity relationships [J].

Almeida, TA ;

Rojo, J ;

Nieto, PM ;

Pinto, FM ;

Hernandez, M ;

Martín, JD ;

Candenas, ML .

CURRENT MEDICINAL CHEMISTRY, 2004, 11 (15) :2045-2081

[7] NK1 receptor stimulation causes contraction and inositol phosphate increase in medium-size human isolated bronchi [J].

Amadesi, S ;

Moreau, J ;

Tognetto, M ;

Springer, J ;

Trevisani, M ;

Naline, E ;

Advenier, C ;

Fisher, A ;

Vinci, D ;

Mapp, C ;

Miotto, D ;

Cavallesco, G ;

Geppetti, P .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (05) :1206-1211

[8] SCH 206272:: a potent, orally active tachykinin NK1, NK2, and NK3 receptor antagonist [J].

Anthes, JC ;

Chapman, RW ;

Richard, C ;

Eckel, S ;

Corboz, M ;

Hey, JA ;

Fernandez, X ;

Greenfeder, S ;

McLeod, R ;

Sehring, S ;

Rizzo, C ;

Crawley, Y ;

Shih, NY ;

Piwinski, J ;

Reichard, G ;

Ting, P ;

Carruthers, N ;

Cuss, FM ;

Billah, M ;

Kreutner, W ;

Egan, RW .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 450 (02) :191-202

[9] NK1 receptor antagonist CP-99,994 inhibits cigarette smoke-induced neutrophil and eosinophil adhesion in rat tracheal venules [J].

Baluk, P ;

Bertrand, C ;

Geppetti, P ;

McDonald, DM ;

Nadel, JA .

EXPERIMENTAL LUNG RESEARCH, 1996, 22 (04) :409-418

[10] Neurogenic inflammation in the airways [J].

Barnes, PJ .

RESPIRATION PHYSIOLOGY, 2001, 125 (1-2) :145-154

← 1 2 3 4 5 6 7 8 9 10 →