Structure of matrix metalloproteinase-3 with a platinum-based inhibitor

被引：11

作者：

Belviso, Benny Danilo ^{[1
]}

Caliandro, Rocco ^{[1
]}

Siliqi, Dritan ^{[1
]}

Calderone, Vito ^{[2
]}

Arnesano, Fabio ^{[3
]}

Natile, Giovanni ^{[3
]}

机构：

[1] CNR, Inst Crystallog, I-70126 Bari, Italy

[2] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, Italy

[3] Univ Bari A Moro, Dept Chem, I-70125 Bari, Italy

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 48期

关键词：

RHEUMATOID-ARTHRITIS; REVEAL; DESIGN; CANCER;

D O I：

10.1039/c3cc41278d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An X-ray investigation has been performed with the aim of characterizing the binding sites of a platinum-based inhibitor (K[PtCl3(DMSO)]) of matrix metalloproteinase-3 (stromelysin-1). The platinum complex targets His224 in the S1' specificity loop, representing the first step in the selective inhibition process (PDB ID code 4JA1).

引用

收藏

页码：5492 / 5494

页数：3

相关论文

共 21 条

[1] Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis [J].

Ahrens, D ;

Koch, AE ;

Pope, RM ;

SteinPicarella, M ;

Niedbala, MJ .

ARTHRITIS AND RHEUMATISM, 1996, 39 (09) :1576-1587

[2] Mechanistic Insight into the Inhibition of Matrix Metalloproteinases by Platinum Substrates [J].

Arnesano, Fabio ;

Boccarelli, Angela ;

Cornacchia, Daniele ;

Nushi, Fiorentin ;

Sasanelli, Rossella ;

Coluccia, Mauro ;

Natile, Giovanni .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (23) :7847-7855

[3] Conformational variability of matrix metalloproteinases: Beyond a single 3D structure [J].

Bertini, I ;

Calderone, V ;

Cosenza, M ;

Fragai, M ;

Lee, YM ;

Luchinat, C ;

Mangani, S ;

Terni, B ;

Turano, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (15) :5334-5339

[4] Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12 [J].

Bertini, Ivano ;

Calderone, Vito ;

Fragai, Marco ;

Jaiswal, Rahul ;

Luchinat, Claudio ;

Melikian, Maxime ;

Mylonas, Efstratios ;

Svergun, Dmitri I. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (22) :7011-7021

[5] Intra- and Interdomain Flexibility in Matrix Metalloproteinases: Functional Aspects and Drug Design [J].

Bertini, Ivano ;

Fragai, Marco ;

Luchinat, Claudio .

CURRENT PHARMACEUTICAL DESIGN, 2009, 15 (31) :3592-3605

[6] Determination of metalloproteinases, plasminogen-activators and their inhibitors in the synovial fluids of patients with rheumatoid arthritis during chemical synoviorthesis [J].

Blaser, J ;

Triebel, S ;

Maasjosthusmann, U ;

Romisch, J ;

KrahlMateblowski, U ;

Freudenberg, W ;

Fricke, R ;

Tschesche, H .

CLINICA CHIMICA ACTA, 1996, 244 (01) :17-33

[7] Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry? [J].

Casini, Angela ;

Reedijk, Jan .

CHEMICAL SCIENCE, 2012, 3 (11) :3135-3144

[8]

Chang C, 2001, TRENDS CELL BIOL, V11, pS37, DOI 10.1016/S0962-8924(01)82222-4

[9] Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design [J].

Chen, JM ;

Nelson, FC ;

Levin, JI ;

Mobilio, D ;

Moy, FJ ;

Nilakantan, R ;

Zask, A ;

Powers, R .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (40) :9648-9654

[10] Crystal structure of the stromelysin catalytic domain at 2.0 Å resolution:: Inhibitor-induced conformational changes [J].

Chen, LY ;

Rydel, TJ ;

Gu, F ;

Dunaway, CM ;

Pikul, S ;

Dunham, KM ;

Barnett, BL .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 293 (03) :545-557