Regulation of human telomerase RNA biogenesis and localization

被引：15

作者：

Qin, Jian ^{[1
,2
]}

Autexier, Chantal ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 0C7, Canada

[2] Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada

来源：

RNA BIOLOGY | 2021年 / 18卷 / 03期

基金：

加拿大健康研究院;

关键词：

Telomere; ageing; telomerase; human telomerase RNA; H; ACA box; exosome; PARN; TCAB1; RNA localization; cap hypermethylation; H/ACA SMALL NUCLEOLAR; POLY(A)-SPECIFIC RIBONUCLEASE PARN; DYSKERATOSIS-CONGENITA MUTATIONS; NONCANONICAL POLY(A) POLYMERASE; HOYERAAL-HREIDARSSON SYNDROME; BODY-SPECIFIC LOCALIZATION; MESSENGER-RNA; CAJAL BODIES; REVERSE-TRANSCRIPTASE; NUCLEAR EXPORT;

D O I：

10.1080/15476286.2020.1809196

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maintenance of telomeres is essential for genome integrity and replicative capacity in eukaryotic cells. Telomerase, the ribonucleoprotein complex that catalyses telomere synthesis is minimally composed of a reverse transcriptase and an RNA component. The sequence and structural domains of human telomerase RNA (hTR) have been extensively characterized, while the regulation of hTR transcription, maturation, and localization, is not fully understood. Here, we provide an up-to-date review of hTR, with an emphasis on current breakthroughs uncovering the mechanisms of hTR maturation and localization.

引用

页码：305 / 315

页数：11

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