The frequency of sacroiliitis in familial Mediterranean fever and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis

被引：84

作者：

Kasifoglu, Timucin ^{[1
]}

Calisir, Cueneyt ^{[1
,2
]}

Cansu, Doendue Ue. ^{[1
]}

Korkmaz, Cengiz ^{[1
]}

机构：

[1] Eskisehir Osmangazi Univ, Div Rheumatol, Dept Internal Med, Eskisehir, Turkey

[2] Eskisehir Osmangazi Univ, Dept Radiol, Eskisehir, Turkey

来源：

CLINICAL RHEUMATOLOGY | 2009年 / 28卷 / 01期

关键词：

Ankylosing spondylitis; Familial Mediterranean fever; HLA-B27; MEFV mutations; Sacroiliitis; ANKYLOSING-SPONDYLITIS; ARTHRITIS; AMYLOIDOSIS; DIAGNOSIS; CRITERIA; DISEASE;

D O I：

10.1007/s10067-008-0980-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The objective of this study was to investigate the frequency of sacroiliitis in familial Mediterranean fever (FMF) patients and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis. The study group consisted of 256 FMF patients (male 128, female 128, mean age 27.2 +/- 6.3 years). After evaluation of the medical records, 70 patients (27.4%) were determined to have one or more of musculoskeletal manifestations. Sacroiliitis was determined in 18 (32.7%) FMF patients. The frequency of sacroiliitis among all FMF patients was found to be 7%. HLA-B27 was 47% and 6.3% in FMF patients with and without sacroiliitis, respectively. The frequency of M694V mutations in FMF patients with sacroiliitis was 93.7%. Sacroiliitis may be seen more frequently in FMF patients than expected. HLA-B27 positivity and/or M694V mutation may play a role in the development of sacroiliitis and the severity of seronegative spondyloarthropathy.

引用

页码：41 / 46

页数：6

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