68Ga-PSMA PET/MR with multimodality image analysis for primary prostate cancer

被引：61
作者：
Eiber, Matthias [1 ]
Nekolla, Stephan G. [1 ]
Maurer, Tobias [2 ]
Weirich, Gregor [3 ]
Wester, Hans-Juergen [4 ]
Schwaiger, Markus [1 ]
机构：
[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Nucl Med, D-81675 Munich, Germany
[2] Tech Univ Munich, Klinikum Rechts Isar, Dept Urol, D-81675 Munich, Germany
[3] Tech Univ Munich, Klinikum Rechts Isar, Dept Pathol, D-81675 Munich, Germany
[4] Tech Univ Munich, Pharmaceut Radiochem, Garching, Germany
来源：
ABDOMINAL IMAGING | 2015年 / 40卷 / 06期
关键词：
Prostate cancer; PET/MR; Multiparametric analysis; Ga-68-PSMA; Tumor biology; GA-68-LABELED PSMA LIGAND; CONTRAST-ENHANCED MRI; DIAGNOSIS;
D O I：
10.1007/s00261-014-0301-z
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Current imaging procedures for prostate cancer including positron emission tomography (PET) exhibit considerable limitations and are not always able to meet the diagnostic needs. Recently, a (68)Gallium-labeled ligand of the prostate-specific membrane antigen (Ga-68-PSMA) has been introduced in PET-imaging of prostate cancer with first promising results. Due to relatively exclusive expression of PSMA in prostatic tissue as well as increased expression in prostate cancer, 68 Ga-PSMA was reported to exhibit a favorable lesion to background ratio. Together with the novel development of combined PET/MRI, the combination of excellent morphological detail, multiparametric functional information, and molecular PET data might lead to a significant improvement in detection of prostate cancer. We present an exemplarily case of primary staging using multiparametric Ga-68-PSMA PET/MR by combining molecular and structural information.
引用
收藏
页码：1769 / 1771
页数：3
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