Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities

被引：51

作者：

Soltani, Saman Khalatbari ^{[1
]}

Jamaluddin, Rosita ^{[1
]}

Tabibi, Hadi ^{[2
]}

Yusof, Barakatun Nisak Mohd ^{[1
]}

Atabak, Shahnaz ^{[3
]}

Loh, Su-Peng ^{[1
]}

Rahmani, Leila ^{[4
]}

机构：

[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr & Dietet, Serdang 43400, Selangor, Malaysia

[2] Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr & Food Technol, Natl Nutr & Food Technol Res Inst, Tehran, Iran

[3] Shahid Beheshti Univ Med Sci, Dept Nephrol, Tehran, Iran

[4] Shahid Beheshti Univ Med Sci, Shahid Modares Hosp, Peritoneal Dialysis Ward, Tehran, Iran

来源：

HEMODIALYSIS INTERNATIONAL | 2013年 / 17卷 / 02期

关键词：

Flaxseed; hemodialysis; lipid abnormalities; systemic inflammation; ALPHA-LINOLENIC ACID; CONTROLLED CLINICAL-TRIAL; C-REACTIVE PROTEIN; POSTMENOPAUSAL WOMEN; CONTROLLED CROSSOVER; LUPUS NEPHRITIS; RENAL-FAILURE; DOUBLE-BLIND; SUPPLEMENT; DENSITY;

D O I：

10.1111/j.1542-4758.2012.00754.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammation and lipid abnormalities are two important risk factors for cardiovascular disease in hemodialysis (HD) patients. The present study was designed to investigate the effects of flaxseed consumption on systemic inflammation and serum lipid profile in HD patients with lipid abnormalities. This was an unblinded, randomized clinical trial. Thirty HD patients with dyslipidemia (triglyceride >200mg/dL and/or high-density lipoprotein-cholesterol (HDL-C) <40mg/dL) were randomly assigned to either a flaxseed or control group. Patients in the flaxseed group received 40g/day ground flaxseed for 8 weeks, whereas patients in the control group received their usual diet, without any flaxseed. At baseline and at the end of week 8, 7mL of blood was collected after a 12- to 14-hour fast and serum concentrations of triglyceride, total cholesterol, low-density lipoprotein-cholesterol (LDL-C), HDL-C, and C-reactive protein (CRP) were measured. Serum concentrations of triglyceride (P<0.01), total cholesterol (P<0.01), LDL-C (P<0.01), and CRP (P<0.05) decreased significantly in the flaxseed group at the end of week 8 compared with baseline, whereas serum HDL-C showed a significant increase (P<0.01). These changes in the flaxseed group were significant in comparison with the control group. The study indicates that flaxseed consumption improves lipid abnormalities and reduces systemic inflammation in HD patients with lipid abnormalities.

引用

页码：275 / 281

页数：7

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