5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT1A receptor stimulation on contextual learning in mice

被引：61
作者：
Eriksson, Therese M. [1 ,2 ]
Golkar, Armita [1 ]
Ekstrom, Joanna C. [1 ]
Svenningsson, Per [2 ]
Ogren, Sven Ove [1 ]
机构：
[1] Karolinska Inst, Dept Neurosci, Div Behav Neurosci, Stockholm, Sweden
[2] Karolinska Inst, Dept Physiol & Pharmacol, Sect Translat Neuropharmacol, Stockholm, Sweden
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 596卷 / 1-3期
基金：
英国医学研究理事会;
关键词：
8-OH-DPAT 8-Hydroxy-2-(dipropylamino); tetralin; 5-HT1A receptor; 5-HT7; receptor; Contextual learning; Memory;
D O I：
10.1016/j.ejphar.2008.08.026
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The principal 5-HT1A receptor agonist 8-Hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) impairs several different types of learning. Besides 5-HT1A receptors, 8-OH-DPAT stimulates 5-HT7 receptors, but it is not known whether 5-HT7 receptors contribute to the impairments. The 5-HT7 receptor antagonist (2R)-1-[(3Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl] pyrrolidine (SB-269970) was combined with S-OH-DPAT to dissociate 5-HT1A from 5-HT7 receptor-mediated effects, in the passive avoidance task for emotional learning. SB-269970 intensified impairments caused by 8-OH-DPAT. SB-269970 alone had no effect on memory performance, but moderately decreased retention under suboptimal learning conditions. These findings indicate that 5-HT7 receptor stimulation by 8-OH-DPAT counteracts 5-HT1A receptor-mediated impairments in hippocampal-dependent contextual learning. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码：107 / 110
页数：4
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