5-HT7 receptor stimulation by 8-OH-DPAT counteracts the impairing effect of 5-HT1A receptor stimulation on contextual learning in mice

被引：62

作者：

Eriksson, Therese M. ^{[1
,2
]}

Golkar, Armita ^{[1
]}

Ekstrom, Joanna C. ^{[1
]}

Svenningsson, Per ^{[2
]}

Ogren, Sven Ove ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, Div Behav Neurosci, Stockholm, Sweden

[2] Karolinska Inst, Dept Physiol & Pharmacol, Sect Translat Neuropharmacol, Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 596卷 / 1-3期

基金：

英国医学研究理事会;

关键词：

8-OH-DPAT 8-Hydroxy-2-(dipropylamino); tetralin; 5-HT1A receptor; 5-HT7; receptor; Contextual learning; Memory;

D O I：

10.1016/j.ejphar.2008.08.026

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The principal 5-HT1A receptor agonist 8-Hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) impairs several different types of learning. Besides 5-HT1A receptors, 8-OH-DPAT stimulates 5-HT7 receptors, but it is not known whether 5-HT7 receptors contribute to the impairments. The 5-HT7 receptor antagonist (2R)-1-[(3Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl] pyrrolidine (SB-269970) was combined with S-OH-DPAT to dissociate 5-HT1A from 5-HT7 receptor-mediated effects, in the passive avoidance task for emotional learning. SB-269970 intensified impairments caused by 8-OH-DPAT. SB-269970 alone had no effect on memory performance, but moderately decreased retention under suboptimal learning conditions. These findings indicate that 5-HT7 receptor stimulation by 8-OH-DPAT counteracts 5-HT1A receptor-mediated impairments in hippocampal-dependent contextual learning. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：107 / 110

页数：4

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