Serotonin-2 receptors and human sleep:: Effect of a selective antagonist on EEG power spectra

被引：82

作者：

Landolt, HP ^{[1
]}

Meier, V ^{[1
]}

Burgess, HJ ^{[1
]}

Finelli, LA ^{[1
]}

Cattelin, F ^{[1
]}

Achermann, P ^{[1
]}

Borbély, AA ^{[1
]}

机构：

[1] Univ Zurich, Inst Pharmacol, CH-8006 Zurich, Switzerland

来源：

NEUROPSYCHOPHARMACOLOGY | 1999年 / 21卷 / 03期

关键词：

slow wave sleep; REM sleep; sleep deprivation; slow-wave activity; spindle frequency activity; regional differences;

D O I：

10.1016/S0893-133X(99)00052-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the effect on the sleep EEG, a 1-mg oral dose of SR 46349B, a novel 5-HT2 antagonist, was administered three hours before bedtime. The drug enhanced slow wave sleep (SWS) and reduced stage 2 without affecting subjective sleep quality. In nonREM sleep (NREMS) EEG slow-wave activity (SWA; power within 0.75-4.5 Hz) was increased and spindle frequency activity (SFA; power within 12.25-25 Hz) was decreased. The relative NREMS power spectrum showed a bimodal pattern with the main peak at 1.5 Hz and a secondary peak at 6 Hz. A regional analysis based on bipolar derivations along the anteroposterior axis revealed significant 'treatment' x 'derivation' interactions within the 9-16 Hz range. In enhancing SWA and attenuating SFA, the 5-HT2 receptor antagonist mimicked the effect of sleep deprivation, whereas the pattern of the NREMS spectrum differed. (C) 1999 American College of Neuropsychopharmacology. Published by Elsevier Science Inc.

引用

页码：455 / 466

页数：12

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