DESTINATION: TEZEPELUMAB LONG-TERM SAFETY AND EFFICACY VERSUS PLACEBO IN PATIENTS WITH SEVERE, UNCONTROLLED ASTHMA

被引：1

作者：

Menzies-Gow, A. ^{[1
]}

Wechsler, M. E. ^{[2
]}

Brightling, C. E. ^{[3
]}

Korn, S. ^{[4
,5
]}

Bednarczyk, A. ^{[6
]}

Ponnarambil, S. ^{[7
]}

Almqvist, G. ^{[8
]}

Lawson, K. ^{[9
,10
]}

Caveney, S. ^{[11
]}

Bowen, K. ^{[12
]}

Colice, G. ^{[9
]}

机构：

[1] Royal Brompton & Harefield Hosp, London, England

[2] Natl Jewish Hlth, Denver, CO USA

[3] Univ Leicester, Inst Lung Hlth, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England

[4] IKF Pneumol Mainz, Mainz, Germany

[5] Thoraxklin Heidelberg, Heidelberg, Germany

[6] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Warsaw, Poland

[7] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Cambridge, England

[8] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Gothenburg, Sweden

[9] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Gaithersburg, MD USA

[10] Cytel Inc, Cambridge, MA USA

[11] Amgen Inc, Global Dev, R&D, Thousand Oaks, CA USA

[12] AstraZeneca, BioPharmaceut R&D, Late Stage Dev Resp & Immunol, Biometr, Gaithersburg, MD USA

来源：

THORAX | 2022年 / 77卷

关键词：

D O I：

10.1136/thorax-2022-BTSabstracts.53

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

S47

引用

页码：A32 / A32

页数：1

共 50 条

[41] Efficacy And Safety Of Tezepelumab In Adults With Severe, Uncontrolled Asthma In Asia: Results From The Regional, Phase 3 DIRECTION Study [J].

Yan, Yang ;

Wang, Lihong ;

Huang, Kewu ;

Tang, Wei ;

Berame, Eli ;

Park, Haesim ;

Hunter, Gillian ;

Jiang, Wei ;

Wu, Chengyi ;

Min, Chiju ;

Domek-Lopacinska, Katarzyna ;

Lal, Harbans ;

Molfino, Nestor ;

Ponnarambil, Sandhia ;

Zhong, Nanshan .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2025, 155 (02)

[42] Long-term safety and efficacy of benralizumab in patients with severe, uncontrolled asthma: 1-year results from the BORA phase 3 extension trial [J].

Busse, William W. ;

Bleecker, Eugene R. ;

FitzGerald, J. Mark ;

Ferguson, Gary T. ;

Barker, Peter ;

Sproule, Stephanie ;

Olsson, Richard F. ;

Martin, Ubaldo J. ;

Goldman, Mitchell .

LANCET RESPIRATORY MEDICINE, 2019, 7 (01) :46-59

[43] Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis [J].

Lai, Tianwen ;

Wang, Shaobin ;

Xu, Zhiwei ;

Zhang, Chao ;

Zhao, Yun ;

Hu, Yue ;

Cao, Chao ;

Ying, Songmin ;

Chen, Zhihua ;

Li, Wen ;

Wu, Bin ;

Shen, Huahao .

SCIENTIFIC REPORTS, 2015, 5

[44] Tezepelumab can restore normal lung function in patients with severe, uncontrolled asthma [J].

Pavord, Ian Douglas ;

Brightling, Christopher E. ;

Korn, Stephanie ;

Martin, Nicole ;

Ponnarambil, Sandhia ;

Molfino, Nestor A. ;

Parnes, Jane R. ;

Cook, Bill ;

Ambrose, Christopher S. .

EUROPEAN RESPIRATORY JOURNAL, 2023, 62

[45] Efficacy of Tezepelumab in Severe, Uncontrolled Asthma: Pooled Analysis of the PATHWAY and NAVIGATOR Clinical Trials [J].

Corren, Jonathan ;

Menzies-Gow, Andrew ;

Chupp, Geoffrey ;

Israel, Elliot ;

Korn, Stephanie ;

Cook, Bill ;

Ambrose, Christopher S. ;

Hellqvist, Asa ;

Roseti, Stephanie L. ;

Molfino, Nestor A. ;

Llanos, Jean-Pierre ;

Martin, Neil ;

Bowen, Karin ;

Griffiths, Janet M. ;

Parnes, Jane R. ;

Colice, Gene .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2023, 208 (01) :13-24

[46] Long-term efficacy and safety of omalizumab in patients with persistent uncontrolled allergic asthma: a systematic review and meta-analysis [J].

Tianwen Lai ;

Shaobin Wang ;

Zhiwei Xu ;

Chao Zhang ;

Yun Zhao ;

Yue Hu ;

Chao Cao ;

Songmin Ying ;

Zhihua Chen ;

Wen Li ;

Bin Wu ;

Huahao Shen .

Scientific Reports, 5

[47] Effect of tezepelumab on healthcare utilization in patients with severe, uncontrolled asthma The NAVIGATOR study [J].

Menzies-Gow, Andrew ;

Bourdin, Arnaud ;

Chupp, Geoffrey ;

Israel, Elliot ;

Hellqvist, Asa ;

Hunter, Gillian ;

Roseti, Stephanie L. ;

Ambrose, Christopher S. ;

Llanos, Jean-Pierre ;

Cook, Bill ;

Corren, Jonathan ;

Colice, Gene .

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 2023, 131 (03) :343-+

[48] One-year safety and tolerability of tezepelumab in Japanese patients with severe uncontrolled asthma: results of the NOZOMI study [J].

Shinkai, Masaharu ;

Ebisawa, Motohiro ;

Fukushima, Yasushi ;

Takeuchi, Satomi ;

Okada, Hiroshi ;

Tokiyo, Tatsuro ;

Hayashi, Nobuya ;

Takikawa, Mami ;

Colice, Gene ;

Almqvist, Gun .

JOURNAL OF ASTHMA, 2023, 60 (03) :616-624

[49] Tezepelumab for Patients with Severe Uncontrolled Asthma: A Systematic Review and Meta-Analysis [J].

Zoumot, Zaid ;

Al Busaidi, Nasser ;

Tashkandi, Wail ;

Aljohaney, Ahmed A. ;

Isse, Said ;

Vidyasagar, Kota ;

Ukwaja, Kingsley Nnanna .

JOURNAL OF ASTHMA AND ALLERGY, 2022, 15 :1665-1679

[50] Efficacy of Tezepelumab in Patients with Severe, Uncontrolled Asthma with Respiratory Comorbidities: Results from the Phase 3 NAVIGATOR Study [J].

Carr, Tara ;

Bernstein, Jonathan ;

Cook, Bill ;

Hunter, Gillian ;

Ambrose, Chris ;

Llanos-Ackert, Jean-Pierre ;

Lindsley, Andrew ;

Colice, Gene .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022, 149 (02) :AB152-AB152

← 1 2 3 4 5 →