Uptake of Colloidal Polyelectrolyte-Coated Particles and Polyelectrolyte Multilayer Capsules by Living Cells

被引：135

作者：

Javier, Alumdena Munoz ^{[1
,2
]}

Kreft, Oliver ^{[3
]}

Semmling, Maximilian ^{[2
,4
]}

Kempter, Susanne ^{[1
]}

Skirtach, Andre G. ^{[3
]}

Bruns, Oliver T. ^{[5
]}

del Pino, Pablo ^{[2
]}

Bedard, Mathiey F. ^{[3
]}

Raedler, Joachim ^{[1
]}

Kaes, Josef ^{[4
]}

Plank, Christian ^{[6
]}

Sukhorukov, Gleb B. ^{[3
,7
]}

Parak, Wolfgang J. ^{[1
,2
]}

机构：

[1] Univ Munich, Ctr Nanosci, Munich, Germany

[2] Univ Marburg, Fachbereich Phys, D-3550 Marburg, Germany

[3] Max Planck Inst Colloids & Interfaces, Golm, Germany

[4] Univ Leipzig, Leipzig, Germany

[5] Univ Med Ctr Hamburg Eppendorf, Dept Biochem & Mol Biol Mol Cell Biol, D-20246 Hamburg, Germany

[6] Tech Univ Munich, Munich, Germany

[7] Queen Mary Univ London, Sch Engn & Mat Sci, London, England

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 22期

关键词：

D O I：

10.1002/adma.200703190

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Rigid particles as well as soft capsules can be ingested by cells and stored in acidic compartments around the nucleus. TEM and fluorescence images show that the rigid particles retain their original spherical shape whereas the hollow and thus more flexible capsules are deformed and squeezed upon the incorporation process. Though soft capsules are deformed upon uptake, the cargo loaded into the capsules is not released into the cytosol.

引用

页码：4281 / 4287

页数：7

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