Mendelian Randomization Analysis Support Causal Associations of HbA1c with Circulating Triglyceride, Total and Low-density Lipoprotein Cholesterol in a Chinese Population

被引:6
作者
Jia, Xu [1 ,2 ,3 ]
Hou, Yanan [1 ,2 ,3 ]
Xu, Min [1 ,2 ,3 ]
Zhao, Zhiyun [1 ,2 ,3 ]
Xuan, Liping [1 ,2 ,3 ]
Wang, Tiange [1 ,2 ,3 ]
Li, Mian [1 ,2 ,3 ]
Xu, Yu [1 ,2 ,3 ]
Lu, Jieli [1 ,2 ,3 ]
Bi, Yufang [1 ,2 ,3 ]
Wang, Weiqing [1 ,2 ,3 ]
Chen, Yuhong [1 ,2 ,3 ]
机构
[1] Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med,Minist Hlth,Shanghai Natl Clin Res Ctr Me, State Key Lab Med Genom,Key Lab Endocrine & Metab, Shanghai 200025, Peoples R China
[2] Shanghai Jiao Tong Univ, Rui Jin Hosp, Sch Med, Collaborat Innovat Ctr Syst Biomed, Shanghai 200025, Peoples R China
[3] Shanghai Jiao Tong Univ, Rui Jin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China
基金
中国国家自然科学基金;
关键词
CORONARY-HEART-DISEASE; INSTRUMENTAL VARIABLES; RISK-FACTORS; DIABETIC INDIVIDUALS; GLYCATED HEMOGLOBIN; GENETIC-VARIANTS; COMMON VARIANTS; GENOMIC LOCI; HBA(1C); OXIDATION;
D O I
10.1038/s41598-019-41076-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Previous observational studies supported a positive association of glycated hemoglobin A1c (HbA1c) level with serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). However, the causal relationship between HbA1c and either one of them was unclear in the East Asians. We performed a Mendelian Randomization (MR) analysis in a community-based study sample in Shanghai, China (n = 11,935). To clarify the cause-andeffect relationships of HbA1c with the four interested lipids, an Expanded HbA1c genetic risk score (GRS) with 17 HbAlc-related common variants and a Conservative score by excluding 11 variants were built and adopted as the Instrumental Variables (IVs), respectively. The Expanded HbA1c-GRS was associated with 0.19 unit increment in log-TG (P = 0.009), 0.42 mmol/L TC (P = 0.01), and 0.33 mmol/L LDL-C (P= 0.01); while the Conservative HbA1c-GRS was associated with 0.22 unit in log-TG (P = 0.03), 0.60 mmol/LTC (P= 0.01), and 0.51 mmol/L LDL-C (P= 0.007). No causal relationship was detected for HDL-C. Sensitivity analysis supported the above findings. In conclusions, MR analysis supports a causal role of increased HbA1c level in increment of circulating TG, TC, and LDL-C in a Chinese population.
引用
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页数:9
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