Selective Alkylation of Amines with Alcohols by Cp☆-Iridium(III) Half-Sandwich Complexes

被引：115

作者：

Wetzel, Alexander ^{[1
,2
]}

Woeckel, Simone ^{[1
,2
]}

Schelwies, Mathias ^{[2
]}

Brinks, Marion K. ^{[2
]}

Rominger, Frank ^{[3
]}

Hofmann, Peter ^{[1
,3
]}

Limbach, Michael ^{[1
,2
]}

机构：

[1] CaRLa Catalysis Res Lab, D-69120 Heidelberg, Germany

[2] BASF SE, Synth & Homogeneous Catalysis, D-67056 Ludwigshafen, Germany

[3] Heidelberg Univ, Inst Organ Chem, D-69120 Heidelberg, Germany

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 02期

关键词：

BIOLOGICALLY IMPORTANT LIGANDS; IRIDIUM-CATALYZED ALKYLATION; N-HETEROCYCLIC CARBENE; ASTERISK-IR COMPLEX; CP-ASTERISK; METAL-COMPLEXES; HALFSANDWICH COMPLEXES; ACID COMPLEXES; RUTHENIUM; RHODIUM(III);

D O I：

10.1021/ol303075h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[(CpIr)-Ir-star(Pro)Cl] (Pro = prolinato) was identified among a series of Cp-star-iridium half-sandwich complexes as a highly reactive and selective catalyst for the alkylation of amines with alcohols. It is active under mild conditions in either toluene or water without the need for base or other additives, tolerates a wide range of alcohols and amines, and gives secondary amines in good to excellent isolated yields.

引用

页码：266 / 269

页数：4