SUMO-specific Protease 1 Regulates Mitochondrial Biogenesis through PGC-1α

被引：43

作者：

Cai, Rong ^{[1
]}

Yu, Tingting ^{[1
]}

Huang, Chao ^{[1
,7
]}

Xia, Xuefeng ^{[5
]}

Liu, Xiaobing ^{[2
,7
]}

Gu, Jianmin ^{[4
]}

Xue, Song ^{[4
]}

Yeh, Edward T. H. ^{[6
,7
]}

Cheng, Jinke ^{[1
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Dept Biochem & Mol Cell Biol, Shanghai Key Lab Tumor Microenvironm & Inflammat, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp Affiliated 9, Shanghai 200011, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200438, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai RenJi Hosp Affiliated, Shanghai 200001, Peoples R China

[5] Methodist Hosp, Res Inst, Weill Cornell Sch Med, Houston, TX 77030 USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA

[7] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2012年 / 287卷 / 53期

基金：

中国国家自然科学基金;

关键词：

TRANSCRIPTIONAL CONTROL; SKELETAL-MUSCLE; COACTIVATOR PGC-1-BETA; RECEPTOR-ALPHA; ERR-ALPHA; PHOSPHORYLATION; HOMEOSTASIS; SENP5; AMPK;

D O I：

10.1074/jbc.M112.422626

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator 1 alpha (PGC-1 alpha) is a master regulator of mitochondrial biogenesis in response to changes in the cellular environment, physiological or pathological status of mammals. PGC-1 alpha is known to be modified by SUMO (Small Ubiquitin-like Modifier). However, it is not known whether SUMOylation could affect the function of PGC-1 alpha in mitochondrial biogenesis and that how PGC-1 alpha SUMOylation is regulated. In this study, we have identified the role of Sentrin/SUMO-specific protease 1 (SENP1) as a specific SUMO protease to regulate SUMOylation status of PGC-1 alpha. More importantly, we have also found that SENP1 promotes PGC-1 alpha transcription activity, which is essential for the expression of mitochondrial genes and subsequently mitochondrial biogenesis. Thus, we reveal that the SUMOylation of PGC-1 alpha controlled by SENP1 plays an important role in mitochondrial biogenesis and function.

引用

页码：44464 / 44470

页数：7

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