Pleomorphic lobular carcinoma of the breast: a non-evident diagnosis: case report and reviewof the literature

被引：0
作者：
Azouz, H. [1 ]
Bouraoui, S. [1 ]
Blel, A. [1 ]
Lahmar, A. [1 ]
Limaiem, F. [1 ]
Ben Fadhel, C. [1 ]
Triki, A. [2 ]
Gara, F. [2 ]
Mzabi-Regaya, S. [1 ]
机构：
[1] Hop Mongi Slim, Lab Anat & Cytol Pathol, La Marsa, Tunisia
[2] Hop Mongi Slim, Serv Gynecol Obstet, La Marsa, Tunisia
来源：
ONCOLOGIE | 2008年 / 10卷 / 11期
关键词：
Breast neoplasms; Invasive lobular carcinoma; Invasive pleomorph lobular carcinoma; Invasive ductal carcinoma; Immunochemistry;
D O I：
10.1007/s10269-007-0788-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report a case of a 27-years-old woman with a lesion at the right breast, incidentally noted. The patient underwent tumour resection followed by a right mastectomy type "Patey". Microscopic analysis of the tumour had recognised an invasive pleomorphic lobular carcinoma. Invasive pleomorphic lobular carcinoma (PLC) is a distinctive aggressive subtype of invasive lobular carcinomas (ILC). It has the typical infiltrating pattern of classical ILC of diffuse single cell spread but the nuclei are more pleomorphic. Histological differential diagnosis with ductal carcinoma may be difficult, but it is important for this difference to be done. E-cadherine is a trans-membrane glycoprotein, typically expressed in ductal carcinoma, and loss of E-cadherine expression characterises invasive and in situ lobular carcinoma.
引用
收藏
页码：668 / 672
页数：5
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