Antihypertensive properties of flavonoid-rich apple peel extract

被引：134

作者：

Balasuriya, Nileeka ^{[1
]}

Rupasinghe, H. P. Vasantha ^{[1
]}

机构：

[1] Nova Scotia Agr Coll, Dept Environm Sci, Truro, NS B2N 5E3, Canada

来源：

FOOD CHEMISTRY | 2012年 / 135卷 / 04期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Hypertension; Angiotensin converting enzyme; Flavonoids; Apple; Human umbilical vein endothelial cell; ANGIOTENSIN-CONVERTING ENZYME; PLASMA EXTRAVASATION; BLOOD-PRESSURE; QUERCETIN; INHIBITION; ABSORPTION; PHYTOCHEMICALS; POLYPHENOLS; EXPOSURE; ACE;

D O I：

10.1016/j.foodchem.2012.07.023

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Hypertension is a major public health problem rising across the globe. Inhibition of angiotensin converting enzyme (ACE) is identified as a main therapeutic target in controlling high blood pressure. The present study investigated the ACE inhibitory property of a flavonoid-rich apple peel extract (FAE), its constituents, selected flavonoids and some quercetin metabolites using a biochemical assay of ACE inhibition and a human umbilical vein endothelial cell (HUVEC) model. FAE, all the tested flavonoids except genistein, and two quercetin metabolites (quercetin-3-O-glucuronic acid and quercetin-3-O-sulfate) significantly (p < 0.05) inhibited ACE. Enzyme kinetic analysis revealed that flavonoids are competitive inhibitors of ACE. In the HUVEC model, FAE, quercetin-3-O-glucoside and quercetin-3-O-glucuronic acid inhibited significantly (p < 0.05) ACE activity. Overall, FAE and most of the flavonoids tested showed ACE inhibition in vitro which needs further investigations using animal and human clinical trials. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2320 / 2325

页数：6

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