Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum

被引：111

作者：

Fejzo, Marlena S. ^{[1
,2
]}

Sazonova, Olga V. ^{[3
]}

Sathirapongsasuti, J. Fah ^{[3
]}

Hallgrimsdottir, Ingileif B. ^{[3
,7
]}

Vacic, Vladimir ^{[3
]}

MacGibbon, Kimber W. ^{[4
]}

Schoenberg, Frederic P. ^{[5
]}

Mancuso, Nicholas ^{[6
]}

Slamon, Dennis J. ^{[1
]}

Mullin, Patrick M. ^{[2
]}

机构：

[1] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, David Geffen Sch Med, Div Hematol Oncol, Los Angeles, CA 90095 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Maternal Fetal Med, Div Maternal Fetal Med, Los Angeles, CA 90033 USA

[3] 23andMe Inc, Mountain View, CA 94041 USA

[4] Hyperemesis Educ & Res Fdn, Damascus, OR 97089 USA

[5] Univ Calif Los Angeles, Dept Stat, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[7] Amgen Inc, San Francisco, CA 94080 USA

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

GENOME-WIDE ASSOCIATION; MACROPHAGE INHIBITORY CYTOKINE-1; DIFFERENTIATION FACTOR 15; MACULAR DEGENERATION; PREGNANCY; NAUSEA; SERUM; RESOURCE; LOCI;

D O I：

10.1038/s41467-018-03258-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hyperemesis gravidarum (HG), severe nausea and vomiting of pregnancy, occurs in 0.3-2% of pregnancies and is associated with maternal and fetal morbidity. The cause of HG remains unknown, but familial aggregation and results of twin studies suggest that understanding the genetic contribution is essential for comprehending the disease etiology. Here, we conduct a genome-wide association study (GWAS) for binary (HG) and ordinal (severity of nausea and vomiting) phenotypes of pregnancy complications. Two loci, chr19p13.11 and chr4q12, are genome-wide significant (p < 5 x 10(-8)) in both association scans and are replicated in an independent cohort. The genes implicated at these two loci are GDF15 and IGFBP7 respectively, both known to be involved in placentation, appetite, and cachexia. While proving the casual roles of GDF15 and IGFBP7 in nausea and vomiting of pregnancy requires further study, this GWAS provides insights into the genetic risk factors contributing to the disease.

引用

页数：9

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