Enhancing engraftment of cord blood cells via insight into the biology of stem/progenitor cell function

被引：16

作者：

Broxmeyer, Hal E. ^{[1
]}

机构：

[1] Indiana Univ Sch Med, Dept Microbiol & Immunol, Indianapolis, IN 46202 USA

来源：

HEMATOPOIETIC STEM CELLS VIII | 2012年 / 1266卷

基金：

美国国家卫生研究院;

关键词：

cord blood; stem and progenitor cells; intracellular signals; cytokines; HEMATOPOIETIC STEM-CELLS; UNRELATED BONE-MARROW; MULTIPOTENTIAL PROGENITOR CELLS; HIGH-EFFICIENCY RECOVERY; TAT-INTERACTING PROTEIN; EX-VIVO EXPANSION; CD26; INHIBITION; PLACENTAL-BLOOD; ACUTE-LEUKEMIA; REPLATING CAPACITY;

D O I：

10.1111/j.1749-6632.2012.06509.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cord blood (CB) transplantation has been used over the last 24 years to treat patients with malignant and nonmalignant disorders. CB has its advantages and disadvantages compared with other sources of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) for transplantation. More knowledge of the cytokines and intracellular signaling molecules regulating HSCs and HPCs could be used to modulate these regulators for clinical benefit. This review provides information about the general field of CB transplantation and about studies from the author's laboratory that focus on regulation of HSCs and HPCs by CD26/DPPIV, SDF-1/CXCL12, the Rheb2-mTOR pathway, SIRT1, DEK, cyclin-dependent kinase inhibitors, and cytokines/growth factors. Cryopreservation of CB HSCs and HPCs is also briefly discussed.

引用

页码：151 / 160

页数：10

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