Polymeric monolithic materials modified with nanoparticles for separation and detection of biomolecules: A review

被引：54

作者：

Connolly, Damian ^{[2
]}

Currivan, Sinead ^{[2
]}

Paull, Brett ^{[1
]}

机构：

[1] Univ Tasmania, Sch Chem, Australian Ctr Res Separat Sci ACROSS, Hobart, Tas 7001, Australia

[2] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

来源：

PROTEOMICS | 2012年 / 12卷 / 19-20期

关键词：

Biomolecules; Detection; Nanoparticles; Polymer monoliths; Separation; Technology; PERFORMANCE LIQUID-CHROMATOGRAPHY; LESS COMMON APPLICATIONS; EXCHANGE STATIONARY PHASES; POROUS SILICA COLUMNS; CARBON NANOTUBES; GOLD NANOPARTICLES; CAPILLARY-COLUMNS; ELECTROCHEMICAL SENSORS; PSEUDOSTATIONARY PHASES; SELECTIVE ENRICHMENT;

D O I：

10.1002/pmic.201200142

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Polymer monolithic materials have found particularly utility in the field of bioanalysis, particularly in the area of separation science, for both enrichment and trapping of biomolecules and their analytical/preparative separations. Nanoparticle-modified monoliths have recently emerged as a new class of substrate, with unique characteristics and structure, and with selectively tailored surface chemistries for target molecules. Although several reviews exist on the applications of nanoparticles in analytical science, this review is the first to specifically summarise the applications in bioanalysis of nanoparticle-modified polymer monolithic materials. The review covers the range of nanoparticles being utilised in this way, their specific applications and future trends.

引用

页码：2904 / 2917

页数：14

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