Twenty-four Month Outcomes in the Collaborative Ocular Tuberculosis Study (COTS)-1: Defining the "Cure" in Ocular Tuberculosis

被引：15

作者：

Agarwal, Aniruddha ^{[1
]}

Agrawal, Rupesh ^{[2
,3
,4
,5
]}

Raje, Dhananjay ^{[6
]}

Testi, Ilaria ^{[5
]}

Mahajan, Sarakshi ^{[7
]}

Gunasekeran, Dinesh Visva ^{[2
,3
]}

Aggarwal, Kanika ^{[6
]}

Murthy, Somasheila, I ^{[8
,9
]}

Westcott, Mark ^{[5
,6
]}

Chee, Soon-Phaik ^{[2
,4
,10
,11
,12
]}

Mccluskey, Peter ^{[13
]}

Ho, Su Ling ^{[3
]}

Teoh, Stephen ^{[3
]}

Cimino, Luca ^{[14
]}

Biswas, Jyotirmay ^{[15
]}

Narain, Shishir ^{[16
]}

Agarwal, Manisha ^{[17
]}

Mahendradas, Padmamalini ^{[18
]}

Khairallah, Moncef ^{[19
]}

Jones, Nicholas ^{[20
]}

Tugal-Tutkun, Ilknur ^{[21
]}

Babu, Kalpana ^{[22
]}

Basu, Soumayava ^{[23
]}

Carreno, Ester ^{[24
]}

Lee, Richard ^{[5
]}

Al-Dhibi, Hassan ^{[25
]}

Bodaghi, Bahram ^{[26
]}

Invernizzi, Alessandro ^{[27
]}

Goldstein, Debra A. ^{[28
]}

Herbort, Carl P. ^{[29
,30
]}

Barisani-Asenbauer, Talin ^{[31
]}

Gonzalez-Lopez, Julio J. ^{[32
]}

Androudi, Sofia ^{[33
]}

Bansal, Reema ^{[1
]}

Moharana, Bruttendu ^{[1
]}

Degli Esposti, Simona ^{[5
]}

Tasiopoulou, Anastasia ^{[5
]}

Nadarajah, Sengal ^{[5
]}

Agarwal, Mamta ^{[15
]}

Abraham, Sharanya ^{[15
]}

Vala, Ruchi ^{[18
]}

Singh, Ramandeep ^{[1
]}

Sharma, Aman ^{[34
]}

Sharma, Kusum ^{[35
]}

Zierhut, Manfred ^{[36
]}

Kon, Onn Min ^{[37
]}

Cunningham, Emmett T. ^{[38
]}

Kempen, John H. ^{[39
,40
,41
]}

Quan Dong Nguyen ^{[8
]}

Pavesio, Carlos ^{[5
]}

机构：

[1] Postgrad Inst Med Educ & Res PGIMER, Adv Eye Ctr, Chandigarh, India

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[3] Tan Tock Seng Hosp, Natl Healthcare Grp Eye Inst, Singapore, Singapore

[4] Singapore Eye Res Inst, Dept Ophthalmol, Singapore, Singapore

[5] NHS Fdn Trust, Moorfields Eye Hosp, Dept Ophthalmol, London, England

[6] UCL Inst Ophthalmol, Dept Stat, London, England

[7] MDS Bioanalyt, Dept Ophthalmol, Nagpur, India

[8] Stanford Univ, Byres Eye Inst, Palo Alto, CA 94304 USA

[9] LV Prasad Eye Inst, Tej Kohli Cornea Inst, Dept Ophthalmol, Kallam Anji Reddy Campus, Hyderabad, India

[10] Singapore Natl Eye Ctr, Singapore, Singapore

[11] Duke NUS Med Sch, Dept Ophthalmol, Singapore, Singapore

[12] Duke NUS Med Sch, Visual Sci Acad Clin Program, Singapore, Singapore

[13] Univ Sydney, Cent Clin Sch, Save Sight Inst, Dept Clin Ophthalmol & Eye Hlth, Sydney, NSW, Australia

[14] Azienda USL IRCCS, Ocular Immunol Unit, Reggio, Italy

[15] Sankara Nethralaya, Dept Ophthalmol, Chennai, Tamil Nadu, India

[16] Shroff Eye Ctr, Dept Ophthalmol, New Delhi, India

[17] Dr Shroffs Char Eye Hosp Daryaganj, Dept Ophthalmol, New Delhi, India

[18] Narayana Nethralaya, Dept Uveitis & Ocular Immunol, Bangalore, Karnataka, India

[19] Univ Monastir, Fattouma Bourguiba Univ Hosp, Fac Med, Dept Ophthalmol, Monastir, Tunisia

[20] Univ Manchester, Dept Ophthalmol, Manchester, Lancs, England

[21] Istanbul Univ, Istanbul Fac Med, Dept Ophthalmol, Istanbul, Turkey

[22] Vittala Int Inst Ophthalmol, Prabha Eye Clin & Res Ctr, Bangalore, Karnataka, India

[23] LV Prasad Eye Inst, Dept Ophthalmol, Bhubaneswar, India

[24] Hosp Univ Fdn Jimenez Diaz, Dept Ophthalmol, Madrid, Spain

[25] King Khalid Eye Specialist Hosp, Dept Ophthalmol, Riyadh, Saudi Arabia

[26] Sorbonne Univ, Dept Ophthalmol, DHU SightRestore, Paris, France

[27] Univ Milan, Luigi Sacco Hosp, Dept Biomed & Clin Sci L Sacco, Eye Clin, Milan, Italy

[28] Northwestern Univ, Dept Ophthalmol, Feinberg Sch Med, Chicago, IL 60611 USA

[29] Ctr Ophthalm Specialised Care, Dept Ophthalmol, Lausanne, Switzerland

[30] Univ Lausanne, Lausanne, Switzerland

[31] Med Univ Vienna, Laura Bassi Ctr Expertise Ctr Pathophysiol Infect, Ctr Ocular Inflammat & Infect OCUVAC, Vienna, Austria

[32] Ramon Y Cajal Univ Hosp, Dept Ophthalmol, Madrid, Spain

[33] Univ Thessaly, Dept Ophthalmol, Thessaly, Greece

[34] PGIMER, Dept Rheumatol, Chandigarh, India

[35] PGIMER, Dept Microbiol, Chandigarh, India

[36] Univ Tubingen, Ctr Ophthalmol, Dept Ophthalmol, Tubingen, Germany

[37] Imperial Coll Healthcare NHS Trust, St Marys Hosp, Chest & Allergy Clin, London, England

[38] UCSF Sch Med, Francis I Proctor Fdn, San Francisco, CA USA

[39] Harvard Med Sch, Dept Ophthalmol, Massachusetts Eye & Ear, Boston, MA 02115 USA

[40] MyungSung Christian Med Ctr, MCM Eye Unit, Addis Ababa, Ethiopia

[41] MyungSung Med Sch, Addis Ababa, Ethiopia

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2020年 / 28卷

关键词：

Ocular tuberculosis; uveitis; antitubercular therapy; tuberculous; tubercular uveitis; cure; Collaborative Ocular Tuberculosis Study (COTS) group; UVEITIS;

D O I：

10.1080/09273948.2020.1761401

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose To report the clinical findings, anatomical features, and treatment outcomes in subjects with ocular tuberculosis (OTB) at 24 months in the Collaborative Ocular Tuberculosis Study (COTS)-1. Methods Of the 945 subjects included in COTS-1, those who completed a 24-month follow-up after completion of treatment were included. The main outcome measure was a number of patients with treatment failure (TF). Results 228 subjects (120 males; mean age of 42.82 +/- 14.73 years) were included. Most common phenotype of uveitis was posterior (n= 81; 35.53%), and panuveitis (n= 76; 33.33%). Fifty-two patients (22.81%) had TF. On univariable analysis, odds of high TF was observed with bilaterality (OR: 3.46,p= .003), vitreous haze (OR: 2.14,p= .018), and use of immunosuppressive therapies (OR: 5.45,p= .003). However, only bilaterality was significant in the multiple regression model (OR: 2.84;p= .02). Conclusions Majority of subjects (>75%) achieved cure in the COTS-1 at 24-month follow-up. The concept of "cure" may be a valuable clinical endpoint in trials for OTB.

引用

页码：65 / 73

页数：9

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