Ferroptosis: The Greasy Side of Cell Death

被引：43

作者：

Friedmann Angeli, Jose Pedro ^{[1
]}

Miyamoto, Sayuri ^{[2
]}

Schulze, Almut ^{[3
]}

机构：

[1] Univ Wurzburg, Rudolf Virchow Ctr Expt Biomed, D-97080 Wurzburg, Germany

[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, Brazil

[3] Univ Wurzburg, Theodor Boveri Inst, Bioctr, D-97074 Wurzburg, Germany

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2019年 / 32卷 / 03期

关键词：

LIPID-PEROXIDATION; MOUSE DEVELOPMENT; OXIDATIVE STRESS; MECHANISMS; METABOLISM; EXPRESSION; RESCUE; ROLES; STATE;

D O I：

10.1021/acs.chemrestox.8b00349

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ferroptosis is a form of cell death that requires phospholipid peroxidation and has attracted increased attention, both as a means to eradicate tumors resistant to standard chemotherapy and for its potential contribution to tissue damage such as in ischemia/reperfusion. The center stage taken by phospholipid peroxidation in ferroptosis is highlighted by recent discoveries that demonstrate an intricate regulation of both the metabolism of polyunsaturated fatty acids as well as mechanisms leading to their oxidation. These metabolic steps converge at the point of ferroptosis execution through mechanisms that are now only starting to be understood. In this short review, we provide an appraisal of some of the recent advances in the understanding of the ferroptosis process and also provide some perspectives of where this knowledge could take us.

引用

页码：362 / 369

页数：8

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