Ferroptosis: The Greasy Side of Cell Death

被引：43

作者：

Friedmann Angeli, Jose Pedro ^{[1
]}

Miyamoto, Sayuri ^{[2
]}

Schulze, Almut ^{[3
]}

机构：

[1] Univ Wurzburg, Rudolf Virchow Ctr Expt Biomed, D-97080 Wurzburg, Germany

[2] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508000 Sao Paulo, Brazil

[3] Univ Wurzburg, Theodor Boveri Inst, Bioctr, D-97074 Wurzburg, Germany

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2019年 / 32卷 / 03期

关键词：

LIPID-PEROXIDATION; MOUSE DEVELOPMENT; OXIDATIVE STRESS; MECHANISMS; METABOLISM; EXPRESSION; RESCUE; ROLES; STATE;

D O I：

10.1021/acs.chemrestox.8b00349

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Ferroptosis is a form of cell death that requires phospholipid peroxidation and has attracted increased attention, both as a means to eradicate tumors resistant to standard chemotherapy and for its potential contribution to tissue damage such as in ischemia/reperfusion. The center stage taken by phospholipid peroxidation in ferroptosis is highlighted by recent discoveries that demonstrate an intricate regulation of both the metabolism of polyunsaturated fatty acids as well as mechanisms leading to their oxidation. These metabolic steps converge at the point of ferroptosis execution through mechanisms that are now only starting to be understood. In this short review, we provide an appraisal of some of the recent advances in the understanding of the ferroptosis process and also provide some perspectives of where this knowledge could take us.

引用

页码：362 / 369

页数：8

共 54 条

[1] Modeling the effects of lipid peroxidation during ferroptosis on membrane properties [J].

Agmon, Eran ;

Solon, Jerome ;

Bassereau, Patricia ;

Stockwell, Brent R. .

SCIENTIFIC REPORTS, 2018, 8

[2] Lipoxygenases-Killers against Their Will? [J].

Angeli, Jose Pedro Friedmann ;

Conrad, Marcus .

ACS CENTRAL SCIENCE, 2018, 4 (03) :312-314

[3] Ferroptosis Inhibition: Mechanisms and Opportunities [J].

Angeli, Jose Pedro Friedmann ;

Shah, Ron ;

Pratt, Derek A. ;

Conrad, Marcus .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2017, 38 (05) :489-498

[4] Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice [J].

Angeli, Jose Pedro Friedmann ;

Schneider, Manuela ;

Proneth, Bettina ;

Tyurina, Yulia Y. ;

Tyurin, Vladimir A. ;

Hammond, Victoria J. ;

Herbach, Nadja ;

Aichler, Michaela ;

Walch, Axel ;

Eggenhofer, Elke ;

Basavarajappa, Devaraj ;

Radmark, Olof ;

Kobayashi, Sho ;

Seibt, Tobias ;

Beck, Heike ;

Neff, Frauke ;

Esposito, Irene ;

Wanke, Ruediger ;

Foerster, Heidi ;

Yefremova, Olena ;

Heinrichmeyer, Marc ;

Bornkamm, Georg W. ;

Geissler, Edward K. ;

Thomas, Stephen B. ;

Stockwell, Brent R. ;

O'Donnell, Valerie B. ;

Kagan, Valerian E. ;

Schick, Joel A. ;

Conrad, Marcus .

NATURE CELL BIOLOGY, 2014, 16 (12) :1180-U120

[5] Photosensitized Membrane Permeabilization Requires Contact-Dependent Reactions between Photosensitizer and Lipids [J].

Bacellar, Isabel O. L. ;

Oliyeira, Maria Cecilia ;

Dantas, Lucas S. ;

Costa, Elierge B. ;

Junqueira, Helena C. ;

Martins, Waleska K. ;

Durantini, Andres M. ;

Cosa, Gonzalo ;

Di Mascio, Paolo ;

Wainwright, Mark ;

Miotto, Ronei ;

Cordeiro, Rodrigo M. ;

Miyamoto, Sayuri ;

Baptista, Mauricio S. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 140 (30) :9606-9615

[6] Redox regulation by glutathione needs enzymes [J].

Berndt, Carsten ;

Lillig, Christopher H. ;

Flohe, Leopold .

FRONTIERS IN PHARMACOLOGY, 2014, 5

[7] Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease [J].

Bogdan, Alexander R. ;

Miyazawa, Masaki ;

Hashimoto, Kazunori ;

Tsuji, Yoshiaki .

TRENDS IN BIOCHEMICAL SCIENCES, 2016, 41 (03) :274-286

[8] Alpha-tocopherol inhibits pore formation in oxidized bilayers [J].

Boonnoy, Phansiri ;

Karttunen, Mikko ;

Wong-ekkabut, Jirasak .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2017, 19 (08) :5699-5704

[9] Expression of Inactive Glutathione Peroxidase 4 Leads to Embryonic Lethality, and Inactivation of the Alox15 Gene Does Not Rescue Such Knock-In Mice [J].

Bruetsch, Simone Hanna ;

Wang, Chi Chiu ;

Li, Lu ;

Stender, Hannelore ;

Neziroglu, Nilguen ;

Richter, Constanze ;

Kuhn, Hartmut ;

Borchert, Astrid .

ANTIOXIDANTS & REDOX SIGNALING, 2015, 22 (04) :281-293

[10] The reactive oxygen species- and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the α,β-unsaturated aldehyde 4-hydroacy-2-nonenal to 1,4-dihydroxy-2-nonene [J].

Burczynski, ME ;

Sridhar, GR ;

Palackal, NT ;

Penning, TM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (04) :2890-2897

← 1 2 3 4 5 6 →