Hepatitis B virus X protein plays an important role in gastric ulcers

被引：6
作者：
Guo, Peng-Tao [1 ]
Yang, Dong [2 ]
Sun, Zhe [1 ]
Xu, Hui-Mian [1 ]
机构：
[1] China Med Univ, Affiliated Hosp 1, Dept Surg Oncol, Shenyang 110001, Peoples R China
[2] China Med Univ, Affiliated Hosp 1, Dept Gen Surg, Shenyang 110001, Peoples R China
来源：
ONCOLOGY REPORTS | 2012年 / 28卷 / 05期
关键词：
HBV; GES-1; apoptosis; cell cycle; endoplasmic reticulum stress; LIVER-CELL PROLIFERATION; FAS-MEDIATED APOPTOSIS; HEPATOCELLULAR-CARCINOMA; TRANSGENIC MICE; UP-REGULATION; HBX PROTEIN; IN-VIVO; HEPATOCYTES; ACTIVATION; DEATH;
D O I：
10.3892/or.2012.2011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepartis B virus (HBV) infects many individuals globally each year. Researchers usually focus on the relationship between HBV and liver diseases. In this study, we investigated the effects of HBV infection on gastric mucosa. We detected the levels of HBX protein and mRNA in specimens from sixty-four chronic hepatitis B patients (CHB) with gastric ulcers. We confirmed that HBX could aggravate gastric ulcers according to clinicopathological parameters. In addition, we constructed the pcDNA3.1-HBX plasmid and transfected it into GES-1, a gastric mucosal cell line. The results indicated that HBX could induce apoptosis and G, arrest in GES-1 cells. Insights into the mechanism of HBX action in GES-1 cells were obtained using western blot analysis.
引用
收藏
页码：1653 / 1658
页数：6
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