IgA Nephropathy and Aberrant Glycosylation of Tonsillar, Serum and Glomerular IgA1

被引：0

作者：

Hiki, Yoshiyuki ^{[1
]}

Ito, Akihiko ^{[2
]}

Yamamoto, Yoshihiro ^{[1
]}

Yamamoto, Koichiro ^{[1
]}

Iwase, Hitoo ^{[2
]}

机构：

[1] Fujita Hlth Univ, Sch Hlth Sci & Med, Toyoake, Aichi, Japan

[2] Kitasato Univ, Dept Otorhinolaryngol & Biochem, Sagamihara, Kanagawa, Japan

来源：

RECENT ADVANCES IN TONSILS AND MUCOSAL BARRIERS OF THE UPPER AIRWAYS | 2011年 / 72卷

关键词：

MASS-SPECTROMETRY;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human IgA1, which is the predominant subtype deposited in the glomeruli in IgA nephropathy (IgAN), has a unique mucin-like structure in its hinge region. Several studies suggested that the IgA1 molecules in IgAN patients had an aberrant structure of O-glycans. The paper summarizes the analyses of O-glycan structure in the IgA1 molecules taken from tonsils, sera and glomeruli of patients with IgAN. Hypoglycosylation, especially hypogalactosylation of O-glycans has been observed not only in serum and glomerular IgA1 but also in tonsillar IgA1. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：68 / +

页数：2

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