Conformational changes associated with protein-protein interactions

被引：230

作者：

Goh, CS ^{[1
]}

Milburn, D ^{[1
]}

Gerstein, M ^{[1
]}

机构：

[1] Yale Univ, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2004年 / 14卷 / 01期

关键词：

D O I：

10.1016/j.sbi.2004.01.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Motions related to protein-protein binding events can be surveyed from the perspective of the Database of Macromolecular Movements. There are a number of alternative conceptual models that describe these events, particularly induced fit and pre-existing equilibrium. There is evidence for both alternatives from recent studies of conformational change. However, there is increasing support for the pre-existing equilibrium model, whereby proteins are found to simultaneously exist in populations of diverse conformations.

引用

页码：104 / 109

页数：6

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