Precision Medicine Approach in Prostate Cancer

被引：10

作者：

Assadi, Majid ^{[1
]}

Jokar, Narges ^{[1
]}

Ghasemi, Mojtaba ^{[2
]}

Nabipour, Iraj ^{[3
]}

Gholamrezanezhad, Ali ^{[4
]}

Ahmadzadehfar, Hojjat ^{[5
,6
]}

机构：

[1] Bushehr Univ Med Sci, Bushehr Med Univ Hosp, Dept Mol Imaging & Radionuclide Therapy MIRT, Persian Gulf Nucl Med Res Ctr,Sch Med, Bushehr, Iran

[2] Univ Zahn, Fac Agr, Dept Plant Breeding & Biotechnol PBB, Lab Computat Biotechnol & Bioinformat CBB, Zabol, Iran

[3] Bushehr Univ Med Sci, Persian Gulf Marine Biotechnol Res Ctr, Persian Gulf Biomed Sci Res Inst, Bushehr, Iran

[4] Univ Southern Calif, Keck Sch Med, Dept Radiol, 1500 San Pablo St, Los Angeles, CA 90033 USA

[5] Klinikum Westfalen, Dept Nucl Med, Knappschaftskrankenhaus 1, D-44309 Dortmund, Germany

[6] Univ Hosp Bonn, Dept Nucl Med, Bonn, Germany

来源：

CURRENT PHARMACEUTICAL DESIGN | 2020年 / 26卷 / 31期

关键词：

Castration-resistant prostate cancer; PSMA Theranostic; prostate biomarker; systems biology; network analysis; metabolic network; precision medicine; omics tool; GENE-EXPRESSION SIGNATURES; DIGITAL RECTAL EXAMINATION; BIOCHEMICAL RECURRENCE; RADIOLIGAND THERAPY; URINARY BIOMARKERS; MEMBRANE ANTIGEN; DNA METHYLATION; RADICAL PROSTATECTOMY; BONE-SCINTIGRAPHY; DOUBLING TIME;

D O I：

10.2174/1381612826666200218104921

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Prostate cancer is the most prevalent type of cancer and the second cause of death in men worldwide. Various diagnostic and treatment procedures are available for this type of malignancy, but High-grade or locally advanced prostate cancers showed the potential to develop to lethal phase that can be causing dead. Therefore, new approaches are needed to prolong patients' survival and to improve their quality of life. Precision medicine is a novel emerging field that plays an essential role in identifying new sub-classifications of diseases and in providing guidance in treatment that is based on individual multi-omics data. Multi-omics approaches include the use of genomics, transcriptomics, proteomics, metabolomics, epigenomics and phenomics data to unravel the complexity of a disease-associated biological network, to predict prognostic biomarkers, and to identify new targeted drugs for individual cancer patients. We review the impact of multi-omics data in the framework of systems biology in the era of precision medicine, emphasising the combination of molecular imaging modalities with high-throughput techniques and the new treatments that target metabolic pathways involved in prostate cancer.

引用

页码：3783 / 3798

页数：16

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