Application of Membrane-Selective Electrodes for the Determination of Pioglitazone Hydrochloride in the Presence of Its Acid Degradant or Metformin Hydrochloride in Tablets and Plasma

被引：20

作者：

El-Ghobashy, M. R. ^{[1
]}

Yehia, A. M. ^{[1
]}

Mostafa, A. A. ^{[1
]}

机构：

[1] Cairo Univ, Fac Pharm, Dept Analyt Chem, ET-1562 Cairo, Egypt

来源：

ANALYTICAL LETTERS | 2009年 / 42卷 / 01期

关键词：

Ammonium reineckate; ion selective electrode; metformin hydrochloride; pioglitazone hydrochloride; PVC membranes; sodium tetraphenyl-borate; PHARMACEUTICAL-PREPARATIONS; RETENTION BEHAVIOR; MASS-SPECTROMETRY; LIQUID; CHROMATOGRAPHY; PHASE; DRUGS; GLIMEPIRIDE;

D O I：

10.1080/00032710802568606

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Polyvinyl chloride (PVC) membrane sensors for the determination of pioglitazone hydrochloride (PIO) and metformin hydrochloride (MET) were described by using the ion association complexes between these drugs with either sodium tetraphenyl-borate (TPB) or ammonium reineckate (RNC) counter ions. The performance characteristics of the sensors were evaluated according to IUPAC recommendations, reveal a fast, stable and linear response over the concentration range 3.162 X 10(-5) - 1 X 10(-2) M for PIO and 1 X 10(-3) - 1 X 10(-1) M for MET. The sensors are used for determination of PIO and MET in tablets and plasma. The developed method was found to be simple, accurate and precise when compared with the reported method.

引用

页码：123 / 140

页数：18

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