Drug delivery systems: Entering the mainstream

被引:3569
作者
Allen, TM [1 ]
Cullis, PR
机构
[1] Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada
[2] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada
[3] Inex Pharmaceut Corp, Burnaby, BC V5J 5J8, Canada
关键词
D O I
10.1126/science.1095833
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.
引用
收藏
页码:1818 / 1822
页数:5
相关论文
共 56 条
[1]  
ADLERMOORE J, 1994, BONE MARROW TRANSPL, V14, pS3
[2]   Safety aspects of pegylated liposomal doxorubicin in patients with cancer [J].
Alberts, DS ;
Garcia, DJ .
DRUGS, 1997, 54 (Suppl 4) :30-35
[3]   Ligand-targeted therapeutics in anticancer therapy [J].
Allen, TM .
NATURE REVIEWS CANCER, 2002, 2 (10) :750-763
[4]   Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer [J].
Batist, G ;
Ramakrishnan, G ;
Rao, CS ;
Chandrasekharan, A ;
Gutheil, J ;
Guthrie, T ;
Shah, P ;
Khojasteh, A ;
Nair, MK ;
Hoelzer, K ;
Tkaczuk, K ;
Park, YC ;
Lee, LW .
JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (05) :1444-1454
[5]  
Bolotin Elijah M., 1994, Journal of Liposome Research, V4, P455, DOI 10.3109/08982109409037057
[6]  
BORY C, 1991, ADV EXP MED BIOL, V309, P173
[8]  
Cabanes A, 1998, INT J ONCOL, V12, P1035
[9]  
Chowdhary RK, 2003, J PHARM PHARM SCI, V6, P13
[10]   Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles [J].
Cullis, PR ;
Hope, MJ ;
Bally, MB ;
Madden, TD ;
Mayer, LD ;
Fenske, DB .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON BIOMEMBRANES, 1997, 1331 (02) :187-211