Drug delivery systems: Entering the mainstream

被引：3579
作者：
Allen, TM [1 ]
Cullis, PR
机构：
[1] Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada
[2] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z3, Canada
[3] Inex Pharmaceut Corp, Burnaby, BC V5J 5J8, Canada
来源：
SCIENCE | 2004年 / 303卷 / 5665期
关键词：
D O I：
10.1126/science.1095833
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally. Many of the early problems that hindered the clinical applications of particulate DDS have been overcome, with several DDS formulations of anticancer and antifungal drugs now approved for clinical use. Furthermore, there is considerable interest in exploiting the advantages of DDS for in vivo delivery of new drugs derived from proteomics or genomics research and for their use in ligand-targeted therapeutics.
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收藏
页码：1818 / 1822
页数：5
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