Quinolone-resistant Neisseria gonorrhoeae: Correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles

被引：100
作者：
Deguchi, T
Yasuda, M
Nakano, M
Ozeki, S
Ezaki, T
Saito, I
Kawada, Y
机构：
[1] GIFU UNIV,SCH MED,DEPT MICROBIOL,GIFU 500,JAPAN
[2] TOKYO KYOSAI HOSP,DEPT UROL,TOKYO,JAPAN
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 04期
关键词：
D O I：
10.1128/AAC.40.4.1020
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Fifty-five clinical strains of Neisseria gonorrhoeae were examined for mutations in the gyrA and parC genes and for antimicrobial susceptibility profiles. The MICs of quinolones for 31 strains with alterations in GyrA were significantly higher than the MICs for 24 strains without such alterations. Eleven strains with alterations in both GyrA and ParC were significantly more resistant to fluoroquinolones than those with alterations in GyrA alone. The MICs of cephalosporins for these strains were also significantly higher than those for other strains.
引用
收藏
页码：1020 / 1023
页数：4
相关论文
共 11 条
[1]   NEISSERIA-GONORRHOEAE ACQUIRES MUTATIONS IN ANALOGOUS REGIONS OF GYRA AND PARC IN FLUOROQUINOLONE-RESISTANT ISOLATES [J].
BELLAND, RJ ;
MORRISON, SG ;
ISON, C ;
HUANG, WM .
MOLECULAR MICROBIOLOGY, 1994, 14 (02) :371-380
[2]   DNA GYRASE MUTATIONS IN QUINOLONE-RESISTANT CLINICAL ISOLATES OF NEISSERIA-GONORRHOEAE [J].
DEGUCHI, T ;
YASUDA, M ;
ASANO, M ;
TADA, K ;
IWATA, H ;
KOMEDA, H ;
EZAKI, T ;
SAITO, I ;
KAWADA, Y .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (02) :561-563
[3]   CLONING AND PRIMARY STRUCTURE OF STAPHYLOCOCCUS-AUREUS DNA TOPOISOMERASE-IV - A PRIMARY TARGET OF FLUOROQUINOLONES [J].
FERRERO, L ;
CAMERON, B ;
MANSE, B ;
LAGNEAUX, D ;
CROUZET, J ;
FAMECHON, A ;
BLANCHE, F .
MOLECULAR MICROBIOLOGY, 1994, 13 (04) :641-653
[4]  
Gorwitz Rachel J., 1993, Morbidity and Mortality Weekly Report, V42, P29
[5]   DETECTION OF THE TETM DETERMINANT IN NEISSERIA-GONORRHOEAE [J].
ISON, CA ;
TEKKI, N ;
GILL, MJ .
SEXUALLY TRANSMITTED DISEASES, 1993, 20 (06) :329-333
[6]   SUSCEPTIBILITY OF NEISSERIA-GONORRHOEAE ASSOCIATED WITH PELVIC INFLAMMATORY DISEASE TO CEFOXITIN, CEFTRIAXONE, CLINDAMYCIN, GENTAMICIN, DOXYCYCLINE, AZITHROMYCIN, AND OTHER ANTIMICROBIAL AGENTS [J].
RICE, RJ ;
KNAPP, JS .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (07) :1688-1691
[7]  
Simard Jean-Luc, 1993, P543
[8]   CHARACTERIZATION OF A GYRB MUTATION RESPONSIBLE FOR LOW-LEVEL NALIDIXIC-ACID RESISTANCE IN NEISSERIA-GONORRHOEAE [J].
STEIN, DC ;
DANAHER, RJ ;
COOK, TM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (04) :622-626
[9]  
TANAKA M, 1994, GENITOURIN MED, V70, P90
[10]   QUINOLONE RESISTANCE-DETERMINING REGION IN THE DNA GYRASE GYRA GENE OF ESCHERICHIA-COLI [J].
YOSHIDA, H ;
BOGAKI, M ;
NAKAMURA, M ;
NAKAMURA, S .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (06) :1271-1272
12