Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers

被引：591

作者：

Yan, Xiaohui ^{[1
,9
]}

Hu, Zhongyi ^{[1
]}

Feng, Yi ^{[1
,2
]}

Hu, Xiaowen ^{[1
]}

Yuan, Jiao ^{[1
]}

Zhao, Sihai D. ^{[10
]}

Zhang, Youyou ^{[1
]}

Yang, Lu ^{[1
,12
]}

Shan, Weiwei ^{[1
,9
]}

He, Qun ^{[1
]}

Fan, Lingling ^{[1
,9
]}

Kandalaft, Lana E. ^{[1
,15
,16
]}

Tanyi, Janos L. ^{[3
]}

Li, Chunsheng ^{[1
,3
]}

Yuan, Chao-Xing ^{[4
]}

Zhang, Dongmei ^{[1
,12
]}

Yuan, Huiqing ^{[11
]}

Hua, Keqin ^{[9
]}

Lu, Yiling

Katsaros, Dionyssios ^{[13
]}

Huang, Qihong ^{[14
]}

Montone, Kathleen ^{[5
]}

Fan, Yi ^{[6
]}

Coukos, George ^{[15
,16
]}

Boyd, Jeff ^{[17
]}

Sood, Anil K. ^{[18
,19
]}

Rebbeck, Timothy ^{[7
]}

Mills, Gordon B. ^{[20
]}

Dang, Chi V. ^{[2
,8
]}

Zhang, Lin ^{[1
,3
]}

机构：

[1] Univ Penn, Perelman Sch Med, Ctr Res Reprod & Womens Hlth, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA

[4] Univ Penn, Perelman Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA

[5] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Perelman Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA

[7] Univ Penn, Perelman Sch Med, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA

[8] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA

[9] Fudan Univ, Obstet & Gynecol Hosp, Shanghai Key Lab Female Reprod Endocrine Related, Shanghai 200011, Peoples R China

[10] Univ Illinois, Dept Stat, Champaign, IL 61820 USA

[11] Shandong Univ, Sch Med, Dept Biochem & Mol Biol, Jinan 250012, Peoples R China

[12] Sichuan Univ, West China Med Sch, Chengdu 610041, Peoples R China

[13] Univ Citta Salute, Azienda Osped, Dept Surg Sci Gynecol Oncol, I-10126 Turin, Italy

[14] Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA

[15] Univ Lausanne, Ludwig Ctr Canc Res, CH-1007 Lausanne, Switzerland

[16] Univ Lausanne, Dept Oncol, CH-1007 Lausanne, Switzerland

[17] Fox Chase Canc Ctr, Canc Genome Inst, Philadelphia, PA 19111 USA

[18] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77054 USA

[19] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Non Coding RNA, Houston, TX 77054 USA

[20] Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77054 USA

来源：

CANCER CELL | 2015年 / 28卷 / 04期

关键词：

EPIGENETIC REGULATION; ANNOTATION; EXPRESSION; REVEALS;

D O I：

10.1016/j.ccell.2015.09.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein- coding genes. Using the integrative data generated by this analysis, we present a clinically guided small interfering RNA screening strategy and a co-expression analysis approach to identify cancer driver lncRNAs and predict their functions. This provides a resource for investigating lncRNAs in cancer and lays the groundwork for the development of new diagnostics and treatments.

引用

页码：529 / 540

页数：12

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