The PIK-related kinases intercept conventional signaling pathways

被引：53
作者：
Kuruvilla, FG [1 ]
Schreiber, SL [1 ]
机构：
[1] Harvard Univ, Howard Hughes Med Inst, Dept Chem & Biol Chem, Cambridge, MA 02138 USA
来源：
CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 05期
关键词：
D O I：
10.1016/S1074-5521(99)80070-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Early efforts to place the first cloned mammalian PIK-related kinase, FRAP, into a conventional membrane to nuclear pathway met with little success. More recent data suggest that members of the family of PIK-related kinases act as intracellular sensors that govern radial. and horizontal pathways. These pathways can impinge upon classical membrane to nuclear pathways, as well as components of the cell cycle machinery.
引用
收藏
页码：R129 / R136
页数：8
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