MicroRNAs in the Regulation of MMPs and Metastasis

被引：54

作者：

Abba, Mohammed ^{[1
,2
]}

Patil, Nitin ^{[1
,2
]}

Allgayer, Heike ^{[1
,2
]}

机构：

[1] German Canc Res Ctr, Mol Oncol Solid Tumors, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Med Fac Mannheim, Dept Expt Surg, D-68135 Mannheim, Germany

来源：

CANCERS | 2014年 / 6卷 / 02期

关键词：

microRNAs; MMPs; cancer; metastasis; INHIBITS CELL-MIGRATION; MATRIX METALLOPROTEINASES; LUNG-CANCER; TUMOR-SUPPRESSOR; UP-REGULATION; TRANSCRIPTION FACTOR; PROMOTES MIGRATION; GROWTH-FACTOR; INVASION; EXPRESSION;

D O I：

10.3390/cancers6020625

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs are integral molecules in the regulation of numerous physiological cellular processes including cellular differentiation, proliferation, metabolism and apoptosis. Their function transcends normal physiology and extends into several pathological entities including cancer. The matrix metalloproteinases play pivotal roles, not only in tissue remodeling, but also in several physiological and pathological processes, including those supporting cancer progression. Additionally, the contribution of active MMPs in metastatic spread and the establishment of secondary metastasis, via the targeting of several substrates, are also well established. This review focuses on the important miRNAs that have been found to impact cancer progression and metastasis through direct and indirect interactions with the matrix metalloproteinases.

引用

页码：625 / 645

页数：21

共 123 条

[1] Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer model [J].