Passage times for unbiased polymer translocation through a narrow pore

被引:88
作者
Wolterink, JK [1 ]
Barkema, GT [1 ]
Panja, D [1 ]
机构
[1] Univ Utrecht, Inst Theoret Phys, NL-3508 TD Utrecht, Netherlands
关键词
D O I
10.1103/PhysRevLett.96.208301
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
We study the translocation process of a polymer in the absence of external fields for various pore diameters b and membrane thickness L. The polymer performs Rouse and reptation dynamics. The mean translocation time <tau(t)> that the polymer needs to escape from a cell and the mean dwell time <tau(d)> that the polymer spends in the pore during the translocation process obey scaling relations in terms of the polymer length N, L, and b/R-g, where R-g is the radius of gyration for the polymer. We explain these relations using simple arguments based on polymer dynamics and the equilibrium properties of polymers.
引用
收藏
页数:4
相关论文
共 33 条
[1]   Microsecond time-scale discrimination among polycytidylic acid, polyadenylic acid, and polyuridylic acid as homopolymers or as segments within single RNA molecules [J].
Akeson, M ;
Branton, D ;
Kasianowicz, JJ ;
Brandin, E ;
Deamer, DW .
BIOPHYSICAL JOURNAL, 1999, 77 (06) :3227-3233
[2]   RECONSTITUTION OF A PROTEIN TRANSLOCATION SYSTEM CONTAINING PURIFIED SECY, SECE, AND SECA FROM ESCHERICHIA-COLI [J].
AKIMARU, J ;
MATSUYAMA, SI ;
TOKUDA, H ;
MIZUSHIMA, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (15) :6545-6549
[3]   Anomalous dynamics of translocation [J].
Chuang, J ;
Kantor, Y ;
Kardar, M .
PHYSICAL REVIEW E, 2002, 65 (01) :1-011802
[4]   Massive field-theory approach to surface critical behavior in three-dimensional systems [J].
Diehl, HW ;
Shpot, M .
NUCLEAR PHYSICS B, 1998, 528 (03) :595-647
[5]   TRANSLOCATION OF DNA ACROSS BACTERIAL-MEMBRANES [J].
DREISEIKELMANN, B .
MICROBIOLOGICAL REVIEWS, 1994, 58 (03) :293-316
[6]  
Goerlich Dirk, 1993, Cell, V75, P615
[7]  
Goerlich Dirk, 1996, Science (Washington D C), V271, P1513
[8]   Identification and characterization of a cell membrane nucleic acid channel [J].
Hanss, B ;
Leal-Pinto, E ;
Bruggeman, LA ;
Copeland, TD ;
Klotman, PE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (04) :1921-1926
[9]   Driven DNA transport into an asymmetric nanometer-scale pore [J].
Henrickson, SE ;
Misakian, M ;
Robertson, B ;
Kasianowicz, JJ .
PHYSICAL REVIEW LETTERS, 2000, 85 (14) :3057-3060
[10]   BLOCKADE OF A MITOCHONDRIAL CATIONIC CHANNEL BY AN ADDRESSING PEPTIDE - AN ELECTROPHYSIOLOGICAL STUDY [J].
HENRY, JP ;
CHICH, JF ;
GOLDSCHMIDT, D ;
THIEFFRY, M .
JOURNAL OF MEMBRANE BIOLOGY, 1989, 112 (02) :139-147