Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles

被引：40

作者：

Ryu, Chung-Kyu ^{[1
]}

Lee, Jung Yoon ^{[1
]}

Jeong, Seong Hee ^{[1
]}

Nho, Ji-Hee ^{[1
]}

机构：

[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 01期

关键词：

1H-Pyrrolo[3,2-g]quinoline-4,9-dione; 4,9-dioxo-4,9-dihydro-1H-benzo[f]indole; Antimicrobial compounds; Antifungal; Fungi; Substitution effects; INHIBITION;

D O I：

10.1016/j.bmcl.2008.10.131

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

1H-Pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles would be potent antifungal agents. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：146 / 148

页数：3

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