Synthesis and antifungal activity of 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles

被引：38
作者：
Ryu, Chung-Kyu [1 ]
Lee, Jung Yoon [1 ]
Jeong, Seong Hee [1 ]
Nho, Ji-Hee [1 ]
机构：
[1] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 01期
关键词：
1H-Pyrrolo[3,2-g]quinoline-4,9-dione; 4,9-dioxo-4,9-dihydro-1H-benzo[f]indole; Antimicrobial compounds; Antifungal; Fungi; Substitution effects; INHIBITION;
D O I：
10.1016/j.bmcl.2008.10.131
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
1H-Pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles were synthesized and tested for in vitro antifungal activity against fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that 1H-pyrrolo[3,2-g]quinoline-4,9-diones and 4,9-dioxo-4,9-dihydro-1H-benzo[f]indoles would be potent antifungal agents. (C) 2008 Elsevier Ltd. All rights reserved.
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收藏
页码：146 / 148
页数：3
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