Protective effect of allopurinol in the renal ischemia-reperfusion in uninephrectomized rats

被引：28
作者：
Rhoden, E
Telöken, C
Lucas, M
Rhoden, C
Mauri, M
Zettler, C
Belló-Klein, A
Barros, E
机构：
[1] Fundacao Fac Fed Ciencias Med Porto Alegre, Dept Urol, FFFCMPA, BR-90450140 Porto Alegre, RS, Brazil
[2] Fundacao Fac Fed Ciencias Med Porto Alegre, Dept Pharmacol, FFFCMPA, BR-90450140 Porto Alegre, RS, Brazil
[3] Fundacao Fac Fed Ciencias Med Porto Alegre, Dept Pathol, FFFCMPA, BR-90450140 Porto Alegre, RS, Brazil
[4] Univ Fed Rio Grande Sul, Dept Physiol, Porto Alegre, RS, Brazil
[5] Univ Fed Rio Grande Sul, Dept Nephrol, Porto Alegre, RS, Brazil
来源：
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 2000年 / 35卷 / 04期
关键词：
allopurinol; kidney; ischemia; lipid peroxidation; histology;
D O I：
10.1016/S0306-3623(01)00105-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of allopurinol (an inhibitor of xanthine oxidase) on oxidative stress, renal dysfunction, and histologic alterations was evaluated during the renal ischemia-reperfusion in uninephrectomized rats. Renal malondialdehyde and serum creatinine levels significantly increased after renal ischemia-reperfusion. However, the pretreatment with allopurinol demonstrated a protector effect in these parameters. Renal ischemia-reperfusion provoked a significant renal damage in the operated group. Tubular atrophy and interstitial fibrosis were attenuated by allopurinol when given prior to the surgery. In our study, allopurinol had a strong tendency to exert a beneficial effect during renal ischemia-reperfusion in uninephrectomized rats. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：189 / 193
页数：5
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