Pharmacokinetics and pharmacodynamics of antibiotics in meningitis

被引：72
作者：
Andes, DR
Craig, WA
机构：
[1] Univ Wisconsin, Sch Med, Dept Med, Infect Dis Sect, Madison, WI 53792 USA
[2] Univ Wisconsin, Sch Med, Dept Med, Clin Pharmacol Sect, Madison, WI 53792 USA
[3] William S Middleton Mem Vet Adm Med Ctr, Madison, WI 53705 USA
来源：
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 1999年 / 13卷 / 03期
关键词：
D O I：
10.1016/S0891-5520(05)70096-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
It is the ability of a drug to reach and maintain effective concentrations at the infection site that determines its efficacy. This article reviews the pharmacokinetics and pharmacodynamics of antimicrobials used in the treatment of meningitis. A better understanding of the interrelationship between pharmacokinetics-the time course of antimicrobial concentrations in serum and at the infection site-and pharmacodynamics-the relationships between antimicrobial concentration and antimicrobial effect-should facilitate the establishment of optimal dosage regimens for this life-threatening bacterial infection.
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页码：595 / +
页数：25
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