Pharmacokinetics and pharmacodynamics of antibiotics in meningitis

被引：73

作者：

Andes, DR

Craig, WA

机构：

[1] Univ Wisconsin, Sch Med, Dept Med, Infect Dis Sect, Madison, WI 53792 USA

[2] Univ Wisconsin, Sch Med, Dept Med, Clin Pharmacol Sect, Madison, WI 53792 USA

[3] William S Middleton Mem Vet Adm Med Ctr, Madison, WI 53705 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 1999年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0891-5520(05)70096-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It is the ability of a drug to reach and maintain effective concentrations at the infection site that determines its efficacy. This article reviews the pharmacokinetics and pharmacodynamics of antimicrobials used in the treatment of meningitis. A better understanding of the interrelationship between pharmacokinetics-the time course of antimicrobial concentrations in serum and at the infection site-and pharmacodynamics-the relationships between antimicrobial concentration and antimicrobial effect-should facilitate the establishment of optimal dosage regimens for this life-threatening bacterial infection.

引用

页码：595 / +

页数：25

共 133 条

[1] Once-daily gentamicin therapy for experimental Escherichia coli meningitis [J].