Effects of Natural Products on Mcl-1 Expression and Function

被引：13

作者：

Muller, Florian ^{[1
]}

Cerella, Claudia ^{[1
]}

Radogna, Flavia ^{[1
]}

Dicato, Mario ^{[1
]}

Diederich, Marc ^{[2
]}

机构：

[1] Hop Kirchberg, Lab Biol Mol & Cellulaire Canc, L-2540 Luxembourg, Luxembourg

[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

CURRENT MEDICINAL CHEMISTRY | 2015年 / 22卷 / 30期

基金：

新加坡国家研究基金会;

关键词：

apoptosis; cancer; Mcl-1; natural compounds; TRAIL-INDUCED APOPTOSIS; HUMAN MULTIPLE-MYELOMA; DOWN-REGULATES MCL-1; BCL-2 PROTEIN FAMILY; CELL-DEATH; SIGNAL TRANSDUCER; TARGETING MCL-1; PROSTATE-CANCER; INHIBITION; ACTIVATOR;

D O I：

10.2174/0929867322666150716115435

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.

引用

页码：3447 / 3461

页数：15

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