Ionic Cross-linked Chitosan Beads for Extended Release of Ciprofloxacin: In vitro Characterization

被引：51
作者：
Srinatha, A. [1 ]
Pandit, J. K. [1 ]
Singh, S. [1 ]
机构：
[1] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India
来源：
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2008年 / 70卷 / 01期
关键词：
Beads; chitosan; ciprofloxacin; ionic cross-linking; tripolyphosphate;
D O I：
10.4103/0250-474X.40326
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chitosan beads loaded with ciprofloxacin hydrochloride were fabricated by ionic cross-linking with sodium tripolyphosphate. The beads showed an excellent water retention property. The degradation of fabricated beads was influenced by the pH of test medium. High drug load was achieved within the bead with a short curing time. Drug release was high in acidic medium (pH 1.2) vis-a-vis intestinal medium ( pH 7.4). Ciprofloxacin hydrochloride release increased with an increasing concentration of ciprofloxacin and decreasing proportion of chitosan. Drug release followed both first-order and Higuchi's root time kinetics showing non-Fickian release mechanism.
引用
收藏
页码：16 / 21
页数：6
相关论文
共 50 条
  • [31] In vitro release of metformin from iron (III) cross-linked alginate-carboxymethyl cellulose hydrogel beads
    Swamy, Bala Yerri
    Yun, Yeoung-Sang
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2015, 77 : 114 - 119
  • [32] Ciprofloxacin loaded genipin cross-linked chitosan/heparin nanoparticles for drug delivery application
    Kumar, Govindarajan Venkat
    Su, Chia-Hung
    Velusamy, Palaniyandi
    MATERIALS LETTERS, 2016, 180 : 119 - 122
  • [33] Preparation and Characterization of Poly (ε-lysine)-chitosan Cross-linked by Glutataldehyde
    Wang, Rui
    Yang, Yuxi
    4TH ANNUAL INTERNATIONAL WORKSHOP ON MATERIALS SCIENCE AND ENGINEERING (IWMSE2018), 2018, 381
  • [34] Synthesis and characterization of chitosan hydrogels cross-linked with dicarboxylic acids
    Valderruten, N. E.
    Valverde, J. D.
    Zuluaga, F.
    Ruiz-Durantez, E.
    REACTIVE & FUNCTIONAL POLYMERS, 2014, 84 : 21 - 28
  • [35] Adsorption behavior of reactive dye in aqueous solution on chemical cross-linked chitosan beads
    Chiou, MS
    Li, HY
    CHEMOSPHERE, 2003, 50 (08) : 1095 - 1105
  • [36] SLOW RELEASE DRUG BASED ON HYDROXYUREA/CHITOSAN CROSS-LINKED MATRIX
    Azad, Seta
    Abbas, Layla Jasim
    QUIMICA NOVA, 2024, 47 (04):
  • [37] Chitosan-coated pectin beads: Characterization and in vitro release of mangiferin
    de Souza, Jose Roberto R.
    de Carvalho, Jose Ivan X.
    Trevisan, Maria Teresa S.
    de Paula, Regina C. M.
    Ricardo, Nagila M. P. S.
    Feitosa, Judith P. A.
    FOOD HYDROCOLLOIDS, 2009, 23 (08) : 2278 - 2286
  • [38] Chitosan-Based Ciprofloxacin Extended Release Systems: Combined Synthetic and Pharmacological (In Vitro and In Vivo) Studies
    Egorov, Anton R.
    Kurliuk, Aleh V.
    Rubanik, Vasili V.
    Kirichuk, Anatoly A.
    Khubiev, Omar
    Golubev, Roman
    Lobanov, Nikolai N.
    Tskhovrebov, Alexander G.
    Kritchenkov, Andreii S.
    MOLECULES, 2022, 27 (24):
  • [39] Cross-linked chitosan/pencil clay hybrid beads for the adsorption of reactive black 5
    Khanday, Waheed Ahmad
    Soon, K. A.
    Ahmed, Muthanna J.
    Hummadi, Esam H.
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 285
  • [40] Adsorption characteristics of Reactive Black 5 onto chitosan beads cross-linked with epichlorohydrin
    Kim, Tae-Young
    Park, Seung-Shik
    Cho, Sung-Yong
    JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2012, 18 (04) : 1458 - 1464
12345