Combined detection of breast cancer biomarkers based on plasmonic sensor of gold nanorods

被引：34

作者：

Chen, Shenna ^{[1
]}

Zhao, Qian ^{[1
]}

Zhang, Lingyang ^{[1
]}

Wang, Linqian ^{[2
]}

Zeng, Yunlong ^{[1
]}

Huang, Haowen ^{[1
]}

机构：

[1] Hunan Univ Sci & Technol, Key Lab Theoret Organ Chem & Funct Mol, Hunan Prov Univ Key Lab QSAR QSPR, Minist Educ,Sch Chem & Chem Engn, Xiangtan, Peoples R China

[2] Cent S Univ, Xiangya Med Sch, Affiliated Tumor Hosp, Dept Lab,Hunan Prov Tumor Hosp, Changsha, Hunan, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2015年 / 221卷

基金：

中国国家自然科学基金;

关键词：

Gold nanorods; Breast cancer; Biomarker; Cancer antigen 15-3; Combined detection; TUMOR-MARKERS; CA; 15-3; COPPER; MECHANISM; ANTIGEN; NANOPARTICLES; SPECTROMETRY; EMISSION; ELEMENTS; ION;

D O I：

10.1016/j.snb.2015.08.023

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this study, a combined detection assay for determination of cancer antigen 15-3 (CA15-3) and copper level in breast cancer serum was developed by use of gold nanorod (GNR)-based plasmonic sensor. Rapid detection of tumor marker (CA15-3) can be accomplished through a simple transduction of optical signal induced by immune-reaction between CA15-3 and GNR@CA15-3 antibody. On the other hand, the copper-induced change of localized surface plasmon resonance of GNRs results in a direct readout of optical signal. Therefore, practical application for combined determination of CA15-3 and copper levels of human serum samples of breast cancer was performed. The results are close agreement with those given by the hospital or other standard approach, confirming this assay with high accuracy. The combined detection strategy provides potential applications for early diagnosing and monitoring the progress of malignant tumor. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：1391 / 1397

页数：7

共 35 条

[1] Ultrasensitive Determination of Copper in Complex Biological Media Based on Modulation of Plasmonic Properties of Gold Nanorods [J].