Protective effects of Fructus sophorae extract on collagen-induced arthritis in BALB/c mice

被引：11

作者：

Han, Hyoung-Min ^{[1
]}

Hong, Su-Hyun ^{[2
]}

Park, Heung-Sik ^{[3
]}

Jung, Jae-Chul ^{[3
]}

Kim, Jong-Sik ^{[4
]}

Lee, Yong-Tae ^{[1
]}

Lee, Eun-Woo ^{[5
,6
,7
,8
]}

Choi, Yung-Hyun ^{[2
,5
,6
]}

Kim, Byung-Woo ^{[5
,6
,7
,8
]}

Kim, Cheol-Min ^{[9
,10
]}

Kang, Kyung-Hwa ^{[1
]}

机构：

[1] Dong Eui Univ, Coll Korean Med, Dept Physiol, 52-57 Yangjeongro, Busan 614851, South Korea

[2] Dong Eui Univ, Coll Korean Med, Dept Biochem, Busan 614851, South Korea

[3] NOVAREX Co Ltd, Life Sci R&D Inst, Ochang 363885, Chungcheongbuk, South Korea

[4] Kosin Univ, Coll Med, Dept Anat, Busan 602703, South Korea

[5] Dong Eui Univ, Antiaging Res Ctr, Busan 614714, South Korea

[6] Dong Eui Univ, Blue Bio Ind RIC, Busan 614714, South Korea

[7] Dong Eui Univ, Dept Life Sci, Busan 614714, South Korea

[8] Dong Eui Univ, Dept Biotechnol, Busan 614714, South Korea

[9] Res Ctr Antiaging Technol Dev, Busan 609735, South Korea

[10] Pusan Natl Univ, Coll Med, Dept Biochem, Yangsan 626870, Gyeongsangnam, South Korea

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2017年 / 13卷 / 01期

关键词：

Fructus sophorae extract; Styphnolobium japonicum L; type II collagen-induced arthritis; RHEUMATOID-ARTHRITIS; NITRIC-OXIDE; MATRIX METALLOPROTEINASES; PATHOGENESIS; CYTOKINES; MMP-9;

D O I：

10.3892/etm.2016.3929

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Styphnolobium japonicum (L.) is utilized in Korean medicine for the treatment of various inflammatory diseases. The aim of the present study' was to explore the effects of Fructus sophorae extract (FSE) isolated from the dried ripe fruit of S. japonicum (L.) on the development of type II collagen-induced arthritis (CIA) in BALB/c mice. The CIA mice were orally administered FSE or saline daily for 2 weeks. The incidence and severity of disease and the inflammatory response in the serum and the joint tissues were assessed. Macroscopic and histological investigation indicated that FSE protected against CIA development. FSE was associated with a significant reduction in the levels of total immunoglobulin G2a and proinflammatory cytokines and mediators in the serum. In addition, FSE suppressed the gene expression levels of proinflammatory cytokines and mediators, the mediator of osteoclastic bone remodeling, the receptor activator of nuclear factor kappa-B ligand and matrix metalloproteinases in the joint tissues. The present results suggest that FSE may protect against inflammation and bone damage, and would be a valuable candidate for further investigation as a novel anti-arthritic agent.

引用

页码：146 / 154

页数：9

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