Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance

被引:69
作者
Lyssiotis, Costas A. [1 ]
Son, Jaekyoung [2 ]
Cantley, Lewis C. [1 ]
Kimmelman, Alec C. [2 ]
机构
[1] Weill Cornell Med Coll, Dept Med, New York, NY USA
[2] Dana Farber Canc Inst, Dept Radiat Oncol, Div Genom Stabil & DNA Repair, Boston, MA 02115 USA
关键词
cancer metabolism; NADPH; aspartate aminotransferase; malic enzyme; glutamate dehydrogenase; CELL-PROLIFERATION;
D O I
10.4161/cc.25307
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:1987 / 1988
页数:2
相关论文
共 7 条
[1]   The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4 [J].
Csibi, Alfred ;
Fendt, Sarah-Maria ;
Li, Chenggang ;
Poulogiannis, George ;
Choo, Andrew Y. ;
Chapski, Douglas J. ;
Jeong, Seung Min ;
Dempsey, Jamie M. ;
Parkhitko, Andrey ;
Morrison, Tasha ;
Henske, Elizabeth P. ;
Haigis, Marcia C. ;
Cantley, Lewis C. ;
Stephanopoulos, Gregory ;
Yu, Jane ;
Blenis, John .
CELL, 2013, 153 (04) :840-854
[2]   Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation [J].
Heiden, Matthew G. Vander ;
Cantley, Lewis C. ;
Thompson, Craig B. .
SCIENCE, 2009, 324 (5930) :1029-1033
[3]   Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation [J].
Lunt, Sophia Y. ;
Vander Heiden, Matthew G. .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27, 2011, 27 :441-464
[4]   Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway [J].
Son, Jaekyoung ;
Lyssiotis, Costas A. ;
Ying, Haoqiang ;
Wang, Xiaoxu ;
Hua, Sujun ;
Ligorio, Matteo ;
Perera, Rushika M. ;
Ferrone, Cristina R. ;
Mullarky, Edouard ;
Ng Shyh-Chang ;
Kang, Ya'an ;
Fleming, Jason B. ;
Bardeesy, Nabeel ;
Asara, John M. ;
Haigis, Marcia C. ;
DePinho, Ronald A. ;
Cantley, Lewis C. ;
Kimmelman, Alec C. .
NATURE, 2013, 496 (7443) :101-+
[5]   Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction [J].
Wise, David R. ;
DeBerardinis, Ralph J. ;
Mancuso, Anthony ;
Sayed, Nabil ;
Zhang, Xiao-Yong ;
Pfeiffer, Harla K. ;
Nissim, Ilana ;
Daikhin, Evgueni ;
Yudkoff, Marc ;
McMahon, Steven B. ;
Thompson, Craig B. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (48) :18782-18787
[6]   Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism [J].
Ying, Haoqiang ;
Kimmelman, Alec C. ;
Lyssiotis, Costas A. ;
Hua, Sujun ;
Chu, Gerald C. ;
Fletcher-Sananikone, Eliot ;
Locasale, Jason W. ;
Son, Jaekyoung ;
Zhang, Hailei ;
Coloff, Jonathan L. ;
Yan, Haiyan ;
Wang, Wei ;
Chen, Shujuan ;
Viale, Andrea ;
Zheng, Hongwu ;
Paik, Ji-hye ;
Lim, Carol ;
Guimaraes, Alexander R. ;
Martin, Eric S. ;
Chang, Jeffery ;
Hezel, Aram F. ;
Perry, Samuel R. ;
Hu, Jian ;
Gan, Boyi ;
Xiao, Yonghong ;
Asara, John M. ;
Weissleder, Ralph ;
Wang, Y. Alan ;
Chin, Lynda ;
Cantley, Lewis C. ;
DePinho, Ronald A. .
CELL, 2012, 149 (03) :656-670
[7]   A positive/negative ion-switching, targeted mass spectrometry-based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue [J].
Yuan, Min ;
Breitkopf, Susanne B. ;
Yang, Xuemei ;
Asara, John M. .
NATURE PROTOCOLS, 2012, 7 (05) :872-881