SONO-TRANSITION-METAL CATALYSIS OF ONE-POT THREE-STEP SYNTHESIS OF GLYCOSYL-1,2,3-TRIAZOLES

被引:7
作者
Driowya, Mohsine [1 ,2 ]
Bougrin, Khalid [1 ]
Benhida, Rachid [2 ]
机构
[1] Univ Mohammed V Agdal, Lab Chim Plantes & Synth Organ & Bioorgan, Rabat, Morocco
[2] Univ Nice Sophia Antipolis, Lab Chim Mol Bioact & Aromes, Nice, France
关键词
Acetylation; azidation; 1,3-dipolar cycloaddition; iron-copper catalysis; nucleosides; one pot; 1,2,3-triazoles; ultrasound; 1,3-DIPOLAR CYCLOADDITION REACTION; 1,4-DISUBSTITUTED 1,2,3-TRIAZOLES; CLICK CHEMISTRY; CYTOSTATIC ACTIVITY; EFFICIENT SYNTHESIS; COPPER-FREE; LIGAND-FREE; ULTRASOUND; SONOCHEMISTRY; ANALOGS;
D O I
10.1080/00397911.2012.673043
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
As a continuation of our studies directed at the development of straightforward and sustainable methodologies, we describe herein an original example of a combined effect of ultrasonic activation and iron-copper dual catalysis that allows an efficient and ecofriendly one-pot, three-step route to a new series of nucleoside-substituted triazoles. The reactions were carried out under both conventional and ultrasonic irradiation conditions. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) to view the free supplemental file.
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页码:1808 / 1817
页数:10
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