Histological, Biochemical, and Hematological Effects of Goniothalamin on Selective Internal Organs of Male Sprague-Dawley Rats

被引:28
作者
Kaid, Fahmi [1 ]
Alabsi, A. M. [1 ,2 ]
Alafifi, Nashwan [1 ]
Ali-Saeed, Rola [2 ]
Al-koshab, May Ameen [1 ]
Ramanathan, Anand [3 ]
Ali, A. M. [4 ,5 ,6 ]
机构
[1] Univ Malaya, Dept Oral & Craniofacial Sci, Fac Dent, Kuala Lumpur 50603, Malaysia
[2] MAHSA Univ Jenjarom, Fac Dent, Dept Oral Biol & Biomed Sci, Jenjarom, Malaysia
[3] Univ Malaya, Fac Dent, Dept Oral & Maxillofacial Clin Sci, Kuala Lumpur 50603, Malaysia
[4] Univ Sultan Zainal Abidin, Fac Bioresource & Food Ind, Terengganu 22200, Malaysia
[5] Univ Sultan Zainal Abidin, Inst Agrobiotechnol, Besut 22200, Terengganu Daru, Malaysia
[6] Univ Islam Malaysia, Nat Med Res Ctr, Cyberjaya 63000, Selangor Darul, Malaysia
关键词
HERBAL MEDICINE; APOPTOSIS; HEALTH;
D O I
10.1155/2019/6493286
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Goniothalamin (GTN) is an isolated compound from several plants of the genus Goniothalamus, and its anticancer effect against several cancers was reported. However, there is no scientific data about effects of its higher doses on internal organs. Accordingly, this study aimed to evaluate the acute and subacute effects of higher doses of GTN on the hematology, biochemistry, and histology of selected internal organs of male Sprague-Dawley rats. In acute study, 35 rats were distributed in 5 groups (n=7) which were intraperitoneally (IP) injected with a single dose of either 100, 200, 300, 400, or 500mg/kg of GTN, while extra 7 rats serve as a normal control. In subacute study, 7 rats were IP-injected with a daily dose of 42mg/kg of GTN for 14 days, while another 7 rats serve as a normal control group. The normal controls in both studies were IP-injected simultaneously with 2ml/kg of 10% DMSO in PBS. At the end of both tests, rats were sacrificed to collect blood for hematology and biochemistry and harvest livers, kidneys, lungs, hearts, spleens, and brains for histology. During acute and subacute exposure, no abnormal changes were observed in the hematology, biochemistry, and histology of the internal organs. However, the 300, 400, and 500mg/kg of GTN during acute exposure were associated with morbidities and mortalities. Ultimately, GTN could be safe up to the dose of 200mg/kg, and the dose of 42mg/kg of GTN was tolerated well.
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页数:13
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