Stereoselective intramolecular cycloadditions of homochiral nitrile imines:: synthesis of enantiomerically pure 3,3a-dihydro-pyrazolo[1,5-a][1,4] benzodiazepine-6(4H)-ones

被引：22
作者：
Broggini, G
Garanti, L
Molteni, G
Pilati, T
Ponti, A
Zecchi, G
机构：
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[2] Univ Insubria, Dipartimento Sci Chim Fis & Matemat, I-22100 Como, Italy
[3] CNR, Ctr Studio Relaz Strutt & Reattiv Chim, I-20133 Milan, Italy
来源：
TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 11期
关键词：
D O I：
10.1016/S0957-4166(99)00227-X
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Starting from the commercially available (S)-1-phenylethylamine, we have synthesised the homochiral hydrazonoyl chlorides 4. The intramolecular cycloaddition of the corresponding nitrile imines 5 gave the diastereoisomeric 3,3a-dihydro-pyrazolo[ 1,5-a][1,4]benzodiazepine-6(4H)-ones 6 and 7 in enantiopure form. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：2203 / 2212
页数：10
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