Long-distance retrograde neurotrophic factor signalling in neurons

被引：186
作者：
Harrington, Anthony W.
Ginty, David D. [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Solomon H Snyder Dept Neurosci, Baltimore, MD 21205 USA
来源：
NATURE REVIEWS NEUROSCIENCE | 2013年 / 14卷 / 03期
关键词：
NERVE GROWTH-FACTOR; SPINAL SENSORY NEURONS; AXONAL-TRANSPORT; INTRAAXONAL TRANSLATION; TARGET INNERVATION; DOWNS-SYNDROME; MESSENGER-RNA; MOTOR-NEURONS; MOUSE MODEL; NGF;
D O I：
10.1038/nrn3253
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The specialized architecture of neurons necessitates unique modes of intracellular communication to allow for cell survival, the ability to detect and respond to injury and aspects of neuronal development, such as axon and dendrite growth, plasticity, and synapse and circuit formation. Many of these neuronal processes rely on signal transduction pathways and transcriptional programmes that are activated by retrograde signals originating from target-derived cues that act on distal axons. Here, we review the many functions of long-range distal axon-to-cell body signalling and discuss mechanisms of retrograde target-derived growth factor signalling.
引用
收藏
页码：177 / 187
页数：11
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