Synthesis of Indoles by Copper-Catalyzed Heteroannulation of o-Aminophenylboronic Acid Pinacol Esters with β-Keto Esters

被引：8

作者：

Bunescu, Ala ^{[1
]}

Wang, Qian ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, SB, ISIC, LSPN,BCH 5304, CH-1015 Lausanne, Switzerland

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 24期

基金：

瑞士国家科学基金会;

关键词：

indole; copper catalysis; Chan-Lam reaction; o-aminophenylboronic ester; beta-keto ester; NONREARRANGED MONOTERPENOID UNIT; ENANTIOSELECTIVE TOTAL-SYNTHESIS; COUPLING REACTIONS; DIRECT ANNULATION; BOND FORMATION; C-N; OXIDATIVE TRIFLUOROMETHYLATION; POLYSUBSTITUTED INDOLES; AZAINDOLE SYNTHESIS; LITHIUM-CHLORIDE;

D O I：

10.1055/s-0032-1316813

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed coupling of o-aminophenylboronic acid pinacol esters with beta-keto esters afforded, under mild base-free oxidative conditions, 2,3-disubstituted indoles featuring a key Chan-Lam-type carbon-carbon bond-forming reaction.

引用

页码：3811 / 3814

页数：4

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