Prostaglandins as modulators of immunity

被引：962
作者：
Harris, SG
Padilla, J
Koumas, L
Ray, D
Phipps, RP
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA
[2] Univ Rochester, Sch Med & Dent, James P Wilmot Canc Ctr, Rochester, NY 14642 USA
[3] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA
[4] Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA
[5] Univ Rochester, Sch Med & Dent, Dept Obstet & Gynecol, Rochester, NY 14642 USA
来源：
TRENDS IN IMMUNOLOGY | 2002年 / 23卷 / 03期
关键词：
D O I：
10.1016/S1471-4906(01)02154-8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Prostaglandins are potent lipid molecules that affect key aspects of immunity. The original view of prostaglandins was that they were simply immunoinhibitory. This review focuses on recent findings concerning prostaglandin E-2 (PGE(2)) and the PGD(2) metabolite 15-deoxy-Delta(12,14)-PGJ(2), and their divergent roles in immune regulation. We will highlight how these two seminal prostaglandins regulate immunity and inflammation, and play an emerging role in cancer progression. Understanding the diverse activities of these prostaglandins is crucial for the development of new therapies aimed at immune modulation.
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收藏
页码：144 / 150
页数：7
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